T-COFFEE, Version_9.01 (2011-10-13 19:18:48 - Revision 1115 - Build 7)
Cedric Notredame
CPU TIME:191 sec.
SCORE=47
*
BAD AVG GOOD
*
Human : 50
Chimpanzee : 48
Rat : 54
Mouse : 53
Zebrafish : 31
Fruitfly : 30
Worm : 30
Yeast : 44
Arabidopsis : 30
cons : 47
Human 1 GTTTGGGGCCAGAGTGGGCGAGGCGCGGAGGTCTGGCCT 39
Chimpanzee 1 ATGGCG--------------A------------------ 7
Rat 1 GTTTTGC---A--------------CCTTCGTT--TCCT 20
Mouse 1 GCCAGGGCCTCGTTTT---TTTGCGCGGTCCT--TTCCT 34
Zebrafish 1 TCTTAT---CAAA----------CACAG---T------- 16
Fruitfly 1 GCATG--------------------------T------- 6
Worm 1 TTTAGA------------------TCGG----------- 10
Yeast 1 ATG------------------------G---T------- 5
Arabidopsis 1 CCAG----------------------------------- 4
cons 1 39
Human 40 ATAAAGTAGTCGCGGAGACGGGGTGCTGGTTTGCGT-CG 77
Chimpanzee 8 --------------------------------------- 7
Rat 21 -----------GCGG---C--------GGCTTCTGTC-G 36
Mouse 35 -----------GCGG---C--------GCCTTCCGTCCG 51
Zebrafish 17 ------------------C--------GGTTTCTTT-CA 28
Fruitfly 7 ----------------------------ATT-------- 9
Worm 11 ------------------T--------G----------- 12
Yeast 6 --------------------------------------- 5
Arabidopsis 5 --------------------------------------- 4
cons 40 78
Human 78 TAGTCTCCTGCAGCGTCTGGGGTTTCCGTTGCAGTC-CT 115
Chimpanzee 8 --------------------------------------- 7
Rat 37 T---CTCCTT--GCTTTTT-GCTCTCCCA---GGT---T 63
Mouse 52 T---CGGCTTC-TCGTCTT-GCTCTCTCT---GGTCCCT 82
Zebrafish 29 C--TCTCTCACAACTTCTC-------------------- 45
Fruitfly 10 --------------------------------------T 10
Worm 13 -------AT-----------GTT---T------------ 18
Yeast 6 ---------------TC---------------------- 7
Arabidopsis 5 --------------------------------------- 4
cons 79 117
Human 116 CGGAACCAGGACCTCG-GCGTGGCCTAGCGAGTTATGGC 153
Chimpanzee 8 --------------------------------------- 7
Rat 64 CCG----AGGCCGCCGCGCGTCTCCCGGGGAAGCATGGC 98
Mouse 83 CCGGAGGAGGCCGCCGCGCGTCTCCCGGGGAAGCATGGC 121
Zebrafish 46 -------AGTTTGC-A-TAATCTAC--AGTCAGCATGGT 73
Fruitfly 11 CT-----AAGCTGC--------TC--------------- 21
Worm 19 --------------------------------------- 18
Yeast 8 -------A-----------------------AGCA---- 12
Arabidopsis 5 --------------------------------------- 4
cons 118 156
Human 154 GACGAAGGCCGTGTGCGTGCTGAAGGGCGACGGCCCA-G 191
Chimpanzee 8 --CGAAGGCCGTGTGCGTGCTGAAGGGCGATGGCCCA-G 43
Rat 99 GATGAAGGCCGTGTGCGTGCTGAAGGGCGACGGTCCG-G 136
Mouse 122 GATGAAAGCGGTGTGCGTGCTGAAGGGCGACGGTCCG-G 159
Zebrafish 74 GAACAAGGCCGTTTGTGTGCTTAAAGGCACCGGTGAA-G 111
Fruitfly 22 -----------------TGCT--------ACGGTCA--- 32
Worm 19 -ATGAA------------------------TCTTC---- 28
Yeast 13 --------------------------------GTC---- 15
Arabidopsis 5 --------C--------TTTTGGA---------C-CTCG 17
cons 157 195
Human 192 TGCAGGGCATCATCAATTTCGAGCA-GAAG------GCA 223
Chimpanzee 44 TGCAGGGCATCATCAATTTCGAGCA-GAAG------GCA 75
Rat 137 TGCAGGGCGTCATTCACTTCGAGCA-GAAG------GCA 168
Mouse 160 TGCAGGGAACCATCCACTTCGAGCA-GAAG------GCA 191
Zebrafish 112 TGACCGGCACCGTCTATTTCAATCA-AGAG------GTA 143
Fruitfly 33 -------CACCAT-----------A-GAAG--------- 43
Worm 29 -------------TCACT-----CAGGTCTCCAACGCGA 49
Yeast 16 --------------------------------------- 15
Arabidopsis 18 TG---GGCTA------TAT-----A-GAAA------ACA 35
cons 196 234
Human 224 AGGGCTGGGACGGAGGCTTGTTTGCGAGGCCGCTCCCAC 262
Chimpanzee 76 AGGGCTGGGACGGAGGCTTGTTTGCGAGGCCGCTCCTAC 114
Rat 169 AGGCCCGGGGCGCTGG-----GCG-CAGGCCGCG----- 196
Mouse 192 AGGCCCGGGGCGCGGG-----GCG-CAGGCCGCG----- 219
Zebrafish 144 AAAAATGTC---------TGTTT-TGA-----------T 161
Fruitfly 44 -AT------------------------------------ 45
Worm 50 TTTT-----------T-----CCG-C------------- 58
Yeast 16 -------------------------G------------- 16
Arabidopsis 36 AG------------------TAAC--------------- 41
cons 235 273
Human 263 CCGCTCGTCCCCCCGCGCACCTTTGCTAGGAGCGGGTCG 301
Chimpanzee 115 CCGCTCGTCCCCCCGCGCACCTTTGCTAGGAGCGGGTCG 153
Rat 197 ------GTGACGCGGGGCACCTGTGCG-GGAG------- 221
Mouse 220 ------GTGACGCGGCGCACCTGTGCG-GGAG------- 244
Zebrafish 162 CCATATTTGAAATGACGTTCATG---------------- 184
Fruitfly 46 ------------------AC------------------- 47
Worm 59 --------------------------------------- 58
Yeast 17 -CA------------------------------------ 18
Arabidopsis 42 -------------------------CAAAGAGA------ 49
cons 274 312
Human 302 CCCGCCAGGCCTCGGGGCCGCCCTGGTCCAGCGCCCGGT 340
Chimpanzee 154 CCCGCCAGGCCTCGGGGCTGCCCTGGTCCAGCGCCCGGT 192
Rat 222 CACGCCACGCCC-----CCG------------------C 237
Mouse 245 CACGCCACGCCC-----CCG------------------C 260
Zebrafish 185 --------------------------------------- 184
Fruitfly 48 --------------------------------------- 47
Worm 59 --------AGGT-----CA-------------------- 64
Yeast 19 --------------------------------------- 18
Arabidopsis 50 ------------------------GA---------CGA- 54
cons 313 351
Human 341 CCCGGCCCGTGCCGCCCGGTCGGTGCCTTCGCCCCCAGC 379
Chimpanzee 193 CCCGGCCCGTGCCGCCCGGTCGGTGCCTTCGCCCCCAGC 231
Rat 238 CGCGGCCTGA--------------------GCCC----- 251
Mouse 261 CACGGCCTGA--------------------GCCC----- 274
Zebrafish 185 --------------------------------------- 184
Fruitfly 48 ------CTGG----------------------------- 51
Worm 65 --------------------------------------- 64
Yeast 19 --------------------------------------- 18
Arabidopsis 55 --------------------------------------- 54
cons 352 390
Human 380 GGTGCGGTGCCCAAGTGCTGAGTCACCGGGCGGGCC-CG 417
Chimpanzee 232 GGTGCGGTGCCCAAGTGCTGAGTCACCGGGCGGGCC-CG 269
Rat 252 G---------TTAAATGCTGAGTCACCGC---GGCCTTG 278
Mouse 275 G---------CTAAGTGCTGAGTCACCGT---GGCC-TG 300
Zebrafish 185 --------------------------------------- 184
Fruitfly 52 -----------AAAGTTC--------------------- 58
Worm 65 --------------GTGCTT------------------- 70
Yeast 19 --------------------------------------- 18
Arabidopsis 55 --------------------------------------- 54
cons 391 429
Human 418 GGCGCGGGGCGTGGGACCGAGGCCGCCGCGGGGCTGGGC 456
Chimpanzee 270 GGCGCGGGGTGTGGGACCGAGGCCGCCGCGGGGCTGGGC 308
Rat 279 AG-GCAGG------GGCCG--GGCGCGGGAGAGGGAGG- 307
Mouse 301 GG-GCAGG------GGCTG--GGCGCCGGGAAGCGAGGC 330
Zebrafish 185 --------------------------------------- 184
Fruitfly 59 --------------------------------------- 58
Worm 71 --------------------------------------- 70
Yeast 19 --------------------------------------- 18
Arabidopsis 55 --AGCAA-------AAACA--TTCA----G-AG----AG 73
cons 430 468
Human 457 CTGCGCGTGGCGGGAGCGCGGGGAGGGATTGCCGCGGGC 495
Chimpanzee 309 CTGCGCGTGGCGGGAGCGCGGGGAGGGATTGCCGCGGGC 347
Rat 308 --------------------------------------C 308
Mouse 331 --------------------------------------C 331
Zebrafish 185 -------TAGCAGGAGAGCAGCG---------CGCGCGT 207
Fruitfly 59 --------------------------------------- 58
Worm 71 --------------------------------------- 70
Yeast 19 --------------------GT----------------- 20
Arabidopsis 74 AAA------------------------ATT----CAG-- 82
cons 469 507
Human 496 CGGGGAGGGGCGGGGGCGGGCGTGCTGCCCTCTGTGGTC 534
Chimpanzee 348 CGGGGAGGGGCGGGGGCGGGCGTGCTGCCCTCTGTGGTC 386
Rat 309 CGGGGCGCCGCGGG------------GCCTTCCG----- 330
Mouse 332 CGGGGCGCCGCGGG------------GCCTTCCG----- 353
Zebrafish 208 CGAG------CTAGCATGAAACTACTA-----CGCACTC 235
Fruitfly 59 -------TCAA--C------------TTTTT-------- 68
Worm 71 --------------------------------------- 70
Yeast 21 -------------GT---TAAA----------------- 26
Arabidopsis 83 --------------------C--------ATTTTTGAT- 92
cons 508 546
Human 535 CTTGGGCCGCCGCCGCGGGTCTGTCGTGGTGCCTGGAG- 572
Chimpanzee 387 CTTGGGCCGCCGCCGCGGGTCTGTCGTG-TGCCTGGAG- 423
Rat 331 ----GG--------------------------------- 332
Mouse 354 ----GG---------CGGG-------------------- 359
Zebrafish 236 CATGA------------------TCGA---GATTGAAGA 253
Fruitfly 69 --------------------------------------- 68
Worm 71 --------------------------------------- 70
Yeast 27 -------------------------------------GG 28
Arabidopsis 93 ----A--------------------------GCTCA--- 98
cons 547 585
Human 573 CGGCTGTGCTCGTCCCTTGCTTGGCCGTGTTCTCGTTCC 611
Chimpanzee 424 CGGCTGTGCTCGTCCCTTGCTTGGCCGTGTTCTCGTTCC 462
Rat 333 CGG--------GTCCCTC-----TTCGCGC------C-- 350
Mouse 360 CGG--------GGGCCTC-----CCCGCGC------C-- 377
Zebrafish 254 CGTCTGTTGTCATATTT-----TTACGTAT------GCA 281
Fruitfly 69 ------------------------TCGTTT--------- 74
Worm 71 --------------------------------------- 70
Yeast 29 G-------------------------------------- 29
Arabidopsis 99 ------AGCAC-----TTGATTC-----------TTTCC 115
cons 586 624
Human 612 TGAGGGTCCCGCGGACACCGAGTGGCGCAGTGCCAGGCC 650
Chimpanzee 463 TGAGGGTCCCGCGGACACCGAGTGGCGCAGTGCCAGGCC 501
Rat 351 ----------------CCCGAGTGGCC--------GGGC 365
Mouse 378 ----------------CCGGAGCGGCT--------GGGC 392
Zebrafish 282 TGATG-----------ATAGAGTAGCA---TG------- 299
Fruitfly 75 ----------------------TGA-------------- 77
Worm 71 --------------------------------------- 70
Yeast 30 --------------------------------------- 29
Arabidopsis 116 AAAGGG--------------------------------- 121
cons 625 663
Human 651 CAGCCCGGGGATGGCGAC----TGCGCCTGGGCCCGCCT 685
Chimpanzee 502 CAGCCCGGGGATGGCGAC----TGCGCCTGAGCCCGCCT 536
Rat 366 CGGCCCGA-------GAGAGCGGGCTT------------ 385
Mouse 393 CTGCCCGG-------GAGAGCCGGCTT------------ 412
Zebrafish 300 --------------CAAT----TGCAC------------ 308
Fruitfly 78 --------------------------------------- 77
Worm 71 --ATCCGA-------A----------------------- 77
Yeast 30 --------------------------------------- 29
Arabidopsis 122 --------------------------------------- 121
cons 664 702
Human 686 GGTGTCTTCGCATCCCTCTCCGCTTTCCG---------- 714
Chimpanzee 537 GGTGTCTTCGCATCCCTCTCCGCTTTCCG---------- 565
Rat 386 --------GGCATC------CGCTAT------------- 397
Mouse 413 --------GGCATC------CGTTAT------------- 424
Zebrafish 309 --------GGAATT------TGCTGTGCGAATGCAATGC 333
Fruitfly 78 --------------------------------------- 77
Worm 78 ---------ACATT------CGTCA-------------- 87
Yeast 30 --------------------------------------- 29
Arabidopsis 122 -------------GTT---------TCC----------- 127
cons 703 741
Human 715 --------------------GCTTCAGCGCTCTAGGTCA 733
Chimpanzee 566 --------------------GCTTCAGCGCTCTAGGTCA 584
Rat 398 --------------------------------------- 397
Mouse 425 --------------------------------------- 424
Zebrafish 334 AAATATAAATGACCGAACATGTTTAAAAACACAATGTT- 371
Fruitfly 78 --------------------------------------- 77
Worm 88 --------------------------------------- 87
Yeast 30 --------------------------------------- 29
Arabidopsis 128 --------------------------------------- 127
cons 742 780
Human 734 GGGAGTCTTCGCTTTTGTACAGCTCTAAGGCTAGGAATG 772
Chimpanzee 585 GGGAGTCTTCGCTTTTGTACAGCTCTAAGGCTAGGAATG 623
Rat 398 --------------------------------------- 397
Mouse 425 --------------------------------------- 424
Zebrafish 372 --GAG---------TTGTACA------------------ 381
Fruitfly 78 --------------------------------------- 77
Worm 88 --------------------------------------- 87
Yeast 30 --------------------------------------- 29
Arabidopsis 128 ---------------------------------TGAG-- 131
cons 781 819
Human 773 GTTT-TTATATTTTTAAAAGGCTTTGG-------AAAAC 803
Chimpanzee 624 GTTTATTATATTTTTAAAAGGCTTTGG-------AAAAC 655
Rat 398 --------------------------------------- 397
Mouse 425 --------------------------------------- 424
Zebrafish 382 -----TCCTATTACTAATATTTTGTGCAATGTCGCATCC 415
Fruitfly 78 --------------------------------------- 77
Worm 88 --------------------------------------- 87
Yeast 30 --------------------------------------- 29
Arabidopsis 132 --------------------GTAT--------------- 135
cons 820 858
Human 804 AAAAATACGCAACAGAGACCGTTTGTGTGA---CACTTT 839
Chimpanzee 656 AAAAATACGCAACAGAGACCGTTTGTGTGA---CACTTT 691
Rat 398 --------------------------------------- 397
Mouse 425 --------------------------------------- 424
Zebrafish 416 CATA---------ATAAACCGCT-----GAAAGCA---- 436
Fruitfly 78 --------------------------------------- 77
Worm 88 --------------------------------------- 87
Yeast 30 --------------------------------------- 29
Arabidopsis 136 --------------------GT----------------- 137
cons 859 897
Human 840 GCAGGGAAGTTTGCTGGCCTCTGTTCTAGGTCATGATTG 878
Chimpanzee 692 GCAGGGAAGTTTGCTGGCCTCTGTTCTAGGTCATGATTG 730
Rat 398 -----------------CC--------------CTCTGG 405
Mouse 425 -----------------CC--------------TTCTGG 432
Zebrafish 437 GCTCAGAA----------------------------ATG 447
Fruitfly 78 --------------------------------------- 77
Worm 88 ------------------------------------TT- 89
Yeast 30 --------------------------------------- 29
Arabidopsis 138 ----------TTGCTTTCC--------------TTTTTG 152
cons 898 936
Human 879 GGCTGCAAGGGCAGAGAAGGTAGCCTTGAACAGAGGTCC 917
Chimpanzee 731 GGCTGCAAGGGCAGAGAAGGTAGCCTTCAACAGAGGTCC 769
Rat 406 GGCTGCT---------------GCTTT-T-CCGGTGTCC 427
Mouse 433 GGCTGCT---------------GCTTT-T-CCGGTGTCC 454
Zebrafish 448 ACCTT-------TGATAAGATGGC---------AGGTCT 470
Fruitfly 78 --------------------------T----------AA 80
Worm 90 ---CGCA---------------A---------------C 95
Yeast 30 --------------------------------------- 29
Arabidopsis 153 G----------------------TTTT------------ 157
cons 937 975
Human 918 TTTTCCTCCTCCTAAGCTCCGGGAGCCAGA--GGTTTAA 954
Chimpanzee 770 TTTTCCTCCTCCTAAGCTCCGGGAGCCAGA--GGTTTAA 806
Rat 428 CTGTCCC--------------------ACAGGGGCTCA- 445
Mouse 455 GTGTCCC--------------------ACA--GGCTCA- 470
Zebrafish 471 ---ACGCCCCCCCATGCACG---CGC-AAA-----CTAA 497
Fruitfly 81 --------------------------------------- 80
Worm 96 T-------------------------------------- 96
Yeast 30 --------------------------------------- 29
Arabidopsis 158 --------------------------------------- 157
cons 976 1014
Human 955 CTGACCCTTTTGGGGATTTTTGAGGGCAGTGATCTTAAC 993
Chimpanzee 807 CTGACCTTTTTGGGGATTTTTGAGGGCAGTGATCTTAAC 845
Rat 446 --GACCCTTGTGGCCAC------CGGCTGCATT------ 470
Mouse 471 --GAGCCCCGTGGCCAC------CGGCTGCGAT------ 495
Zebrafish 498 TTAACGCATATG--CTTCCTCAATAGCAG--AC------ 526
Fruitfly 81 -------------------------------AT------ 82
Worm 97 ----------TGG-------------------------- 99
Yeast 30 -------TGATG--CCGGTGTCTCT-------------- 45
Arabidopsis 158 ------------------------------------AAT 160
cons 1015 1053
Human 994 TTTGGGTGCACAGTTAGCTTATTTGAAGATCTTACTAAA 1032
Chimpanzee 846 TTTGGGTGCACAGTTAGCTTATTTGAAGATCTTACTAAA 884
Rat 471 --T-GTT-----GTAAGAATATTTGAACC---TGG---- 494
Mouse 496 --T-GTT-----GTAAGAATATTTGAACC---CGG---- 519
Zebrafish 527 ------------GTTAACTTA------------------ 535
Fruitfly 83 --T-GAT-------TAATTCATTCGAA-------A---- 100
Worm 100 ----------------GCCTATTTGATC----------- 111
Yeast 46 ------------------GGT------------------ 48
Arabidopsis 161 -TT-GTTTCA-------AATCTTAGAT------------ 178
cons 1054 1092
Human 1033 AATACACCAGAGCCCAACCTCCGACCAATTACATCAAAA 1071
Chimpanzee 885 AATACACCAGAGCCCAACCTCAGACCAATTACATCAAAA 923
Rat 495 -------TGGTGCCAAACC--GGACTAAC-GCAGCA--- 520
Mouse 520 -------TGGTGCCAGACC--GGACTAAG-GC------- 541
Zebrafish 536 -------------------------------CA------ 537
Fruitfly 101 -------TG------------------------------ 102
Worm 112 -------------------------TA------------ 113
Yeast 49 -------------------------------GT------ 50
Arabidopsis 179 ------------------CG-------A-TTCT------ 185
cons 1093 1131
Human 1072 CCTGTCCTAGTGCAGGGTGAGTATTGCTGTTTTTTGAAA 1110
Chimpanzee 924 CCTGTCCTAGTGCAGGGTGAGTATTGCTGTTTTTTGAAA 962
Rat 521 ----------AGCAGAACGCAT-TTGTGGCAT-TTTAAA 547
Mouse 542 ----------CGCAGGACGCGT-TTGCGGCAC-TTTAAA 568
Zebrafish 538 --------------------------------------- 537
Fruitfly 103 -------------------------GTGG-----TTAAA 111
Worm 114 --------------------------TGG---------- 116
Yeast 51 --------------------------------------- 50
Arabidopsis 186 -----------TC-------ACTT--TGG-ATTCTTAAA 203
cons 1132 1170
Human 1111 GTTTCCAAAAGTGATTTTGATGTGCACCTACGATTGAGA 1149
Chimpanzee 963 GTTTCCAAAAGTGATTTTGATGTGCACCTACGATTGAGA 1001
Rat 548 GC----C-AAGC---CCTGG------------------- 559
Mouse 569 GC----A-AAGT---CCTGG---G---CTG---T----- 585
Zebrafish 538 --------------------------------------- 537
Fruitfly 112 GC---------------TGT------------------- 116
Worm 117 --------------------------------------- 116
Yeast 51 --------------------------------------- 50
Arabidopsis 204 T----CG-A-TT---CTTGT---C---CTC--------- 218
cons 1171 1209
Human 1150 ACTGTCGTTTGAGGACAGTGGGTGGAGTTTCGTATTTGG 1188
Chimpanzee 1002 ACTGTCGTTTGAGGACAGTGGGTGGGGTTTCGTATTTGG 1040
Rat 560 -CTA---TATTAGGTCAG--GGTCGTG--CCGCAAGGGG 590
Mouse 586 TCTG---TACTAGGTCAG--GGTCGTG--TCGCAAGGCG 617
Zebrafish 538 --------------------------------------- 537
Fruitfly 117 -CTG---------------------CG------------ 121
Worm 117 --------------------------------------- 116
Yeast 51 --------------------------------------- 50
Arabidopsis 219 -------------GTCT-------GTGCT---------- 227
cons 1210 1248
Human 1189 AAATTAGAAGACCTGGAGTTTCCATTACACCGAATTGGC 1227
Chimpanzee 1041 AAATTAGAAGACCTGGAGTTTCCATTACACCGAATTGGC 1079
Rat 591 GAAAGAAAAGAGATGG------CCT-------------- 609
Mouse 618 GAAAGA-AAGAGATGG------CCT-------------- 635
Zebrafish 538 --------------------------------------- 537
Fruitfly 122 TAATTAACGGCGATG------------------------ 136
Worm 117 ----------CGTTG------------------------ 121
Yeast 51 --------------------------------------- 50
Arabidopsis 228 --------------------GATT--------------- 231
cons 1249 1287
Human 1228 ACTTAATAACTGTTGTCGGAGCATTTCTTAAGCCACATT 1266
Chimpanzee 1080 ACTTAATAACTGTTGTGGGAGCATTTCTTAAGCCACATT 1118
Rat 610 --TGGGCAGTTGTTTTGCCACCA------A-G---AG-C 635
Mouse 636 --TGGACAGCCGTCCC-------TTGCTTT-G---CA-C 660
Zebrafish 538 --------------------------------------T 538
Fruitfly 137 --------------------------------------- 136
Worm 122 --------------------------------------- 121
Yeast 51 --------------------------------------T 51
Arabidopsis 232 -TCGAAC---TTTTCC-----GA---------------T 246
cons 1288 1326
Human 1267 TTCG-TAAAGTGGCTTTAAAATTGCTCTGCCAGTAGGCA 1304
Chimpanzee 1119 TTCG-TAAAGTGGTTTTAAAATTGCTCTGCCAGTAGGCA 1156
Rat 636 TCCAAGAAAGAGA------------CCTGACTCTGGTT- 661
Mouse 661 TCCA-GAGAGAGA------------CCCGGCTGTGGGT- 685
Zebrafish 539 GCAA--ACCTTGA------------ACCG-CCATGCGT- 561
Fruitfly 137 -CCAA------G----------------GGCA-CGGTT- 150
Worm 122 -T--------------------------GTT-----GT- 127
Yeast 52 GTCA--A-------------------------------- 56
Arabidopsis 247 TCCA-A------------------CTCCG-CCG------ 259
cons 1327 1365
Human 1305 GGTTGCTAAGATGGTCAGAGACAAACTTCTG-AAC---- 1338
Chimpanzee 1157 GGTTGCTAAGATGATCAGAGACAAACTTCTG-AAC---- 1190
Rat 662 GTTGTCTACGA----CAGCG---AGTCTCTG-AGC---- 688
Mouse 686 TTTTTCTACCA----CAGCG---AGTTTCTG-AG----C 712
Zebrafish 562 -TTGAGTTTGA----TATTG---AGACTTTGTAGC---- 588
Fruitfly 151 --------------------------------------- 150
Worm 128 TG--CCT-TTA----C------------CTT-AATTATC 146
Yeast 57 --------------------------------------- 56
Arabidopsis 260 --AATCTACG-T----ATAG---A-TCTTTG-AG----- 281
cons 1366 1404
Human 1339 GACTCTTG-T--AAAATATACAGAAATATTTTCA----G 1370
Chimpanzee 1191 GACTCTTG-T--AAAATATACAGAAATATTTTCA----G 1222
Rat 689 ACAATTTG-A--AAAGTATACAGAAATATTTTCG----A 720
Mouse 713 ACATTTTGGA--AAAGTACATAGAGATATTTTCG----A 745
Zebrafish 589 GTAGGTTG-CCTGTAGGTTCTTGAGGTATTTACT----T 622
Fruitfly 151 ---------------------------TTCTTCG----A 158
Worm 147 ------------------------ATCATTTTCATCAGA 161
Yeast 57 -----------------------------GTTCG----A 62
Arabidopsis 282 -------G-A--AATGT---------TTTTTTCG----A 297
cons 1405 * * 1443
Human 1371 AACT-----------TTTA----TCAGTAAAATTACAAA 1394
Chimpanzee 1223 AACT-----------GTTA----TCAGTAAAATTACAAA 1246
Rat 721 AACT-----------ACTGCAGTTCTGCAAAAACAC--- 745
Mouse 746 AAAT-----------ACTGTGACCCTGCAAAAACAC--- 770
Zebrafish 623 ---T-----------ATCGAAAGTCTT-AAG--AATT-- 642
Fruitfly 159 A--CAGGAGGTGAGAATCC---------AAAATC----- 181
Worm 162 A--------------------AC-CCACAAAAAC----- 174
Yeast 63 --------------------------------------- 62
Arabidopsis 298 T-TT-----------A----------------------- 301
cons 1444 1482
Human 1395 ACGTGTTGCAAGGAAGGTGCTTGTG--A-TAACACTGTC 1430
Chimpanzee 1247 ACGTGTTGCAAGGAAGGTGCTTGTG--A-TAACACTGTC 1282
Rat 746 ATGCGTCACAAGGAAGATATTTGTGTGGTTAAGAGCGTG 784
Mouse 771 ATGCGTCACAGGGAAGATGTGTGTG--G-TAAGGTTGTG 806
Zebrafish 643 -TACTACAA-GGGGAAAGGTTTGC-----TGAC-TCATG 673
Fruitfly 182 --------------------------------------- 181
Worm 175 --------------------------------------- 174
Yeast 63 -----ACA--GGCTTC----------------------- 71
Arabidopsis 302 -TG-ATC----GGCGGAT--CT----------------A 316
cons 1483 1521
Human 1431 CCC-AGA-ACCTTAGTGAAGTTACCAACTGGTGGAAAAT 1467
Chimpanzee 1283 -CC-AGA-ACCTTAGTGAAGTTACCAACTGGTGGAAAAT 1318
Rat 785 TTC-AGA-GCCTTAGGG-GGTTAACA------------- 807
Mouse 807 TCC-AGA-GCCTTAGGGAGGTTACCGT------------ 831
Zebrafish 674 CTCCTCT-ATCTCT----G-----------T-------- 688
Fruitfly 182 ----------ATTT--G-AACTTCTC------------- 194
Worm 175 --T-AGA-GACATAG-----CTAC--------------- 189
Yeast 72 --------------------------------------- 71
Arabidopsis 317 --C-CGATTCCTTTG---------------C-------- 329
cons 1522 1560
Human 1468 TTTCTCTTGCACTCGGCTTAA----AAATCATGAGGG-A 1501
Chimpanzee 1319 TTTCTCTTGCACTCGGCTTAA----AAATCATGAGGG-A 1352
Rat 808 ------TTGTACTCCTTTTA-------ATCCCGAGAGAA 833
Mouse 832 ----TGTTGTATTCACCTTA-------ATCCCGAGAG-A 858
Zebrafish 689 ------TTGCAGTCATAATTTTGCCAAAT-AGGACAG-A 719
Fruitfly 195 ------T---GCTCGGCAAA-------AT---------- 207
Worm 190 -----A------------AA-------ATTCTGC----- 199
Yeast 72 ---------------------C----------------- 72
Arabidopsis 330 ------TTGTTTTCT------------------------ 338
cons 1561 1599
Human 1502 ATATTTACTA--TACGAATGAGATTCAGTCTTTAAAGGG 1538
Chimpanzee 1353 ATATTTACTA--TATGAATGAGATTCAGTCTTTAAAGGG 1389
Rat 834 ATATTTGATA--AATGAGCGTTATGTACTCTCTAAAGTG 870
Mouse 859 ATATTTGATA--AATGAGCGTTATGTGCTCTCTGAAGTG 895
Zebrafish 720 ------GATCACAGCACGCTTTAAATGCTGA-TAGAGCT 751
Fruitfly 208 ---------G--TACGAA--------------------- 214
Worm 200 ---------------GAC--------------------- 202
Yeast 73 --------------------------------------- 72
Arabidopsis 339 ---TTGGATG--TATCA--------CACTC--------- 355
cons 1600 1638
Human 1539 GTTTACAGAAA-------CGTGAGAGGACAGGAACAGTT 1570
Chimpanzee 1390 GTTTACAGAAA-------CGTGAGAGGACAGGAACAGTT 1421
Rat 871 GTTTACATAAA-------TGTGAGGAGACCGACACC-AT 901
Mouse 896 GTGGACATACG-------TGTGAGAAGGCAGACACC-AT 926
Zebrafish 752 TA-----TTAC-------TGTATTG-GTGTGGCATC--- 774
Fruitfly 215 --------AAACAGAAGTTC------------------- 226
Worm 203 --------------------CGAGAG-GCGGGT------ 214
Yeast 73 --------------------------------------- 72
Arabidopsis 356 ----------T-------TCTGAAGATGC------C-T- 369
cons 1639 1677
Human 1571 AGTCTGTG-TAAATGTCTGAAATATA-TGTGAGGGAGAT 1607
Chimpanzee 1422 AGTCTGTG-TAAATGTCTGAAATATA-TGTGAGGGAGAT 1458
Rat 902 AGTGAATC-CAAGTGTTTCCTTTATGAGGAGA-ACTGAT 938
Mouse 927 AGTGAATCCCAAGTGTTTGGTTTACGACGAGA-ACTGAT 964
Zebrafish 775 --TGAATA-CA--CATTTACTTG-----------CTGTT 797
Fruitfly 227 ---------TAAAGGT--------------CA-AATAGC 241
Worm 215 --------------------------------------- 214
Yeast 73 ---GAATC-CG--AGCCAAC------------------- 86
Arabidopsis 370 --TGA-C--C---T-----TTTT--A-TGTGA-ACTAGT 391
cons 1678 1716
Human 1608 AATG--A--GTTTAGCCTTTTTCTTTAATAGGTCTCCAG 1642
Chimpanzee 1459 AATG--A--GTTTAGCCTTTTTCTTTAATAGGTCTCCAG 1493
Rat 939 AACGGGA--ATTTAGAGTTTTTCATAACTA-GTCTC--- 971
Mouse 965 AACGGCA--ATTTAGAGTTTTTCGTAACTA-GCCTC--- 997
Zebrafish 798 AAGC--GCTATTTACTGTTTGTGT--------------- 819
Fruitfly 242 --CGGCT--G----------------------------- 247
Worm 215 -ACA-CA-CA----------------------------- 221
Yeast 87 --------------------------------------- 86
Arabidopsis 392 AA------------GAGTTATT-A--------------- 402
cons 1717 1755
Human 1643 ATTTTCTGGAAAAGGTTCTTTGGCATTTGACTCCATTTT 1681
Chimpanzee 1494 ATTTTCTGGAAAAGGTTCTTTGGCATTTGACTCCATTTT 1532
Rat 972 ------------A-GTTTCTTGGCATTTAAATGTATTTT 997
Mouse 998 GTTTCCAGC---A-GTTTCTTGGCATTGAAATGCGTTTT 1032
Zebrafish 820 --------------------TAGTCCCAAATCTCGTTAT 838
Fruitfly 248 --------------------------------------- 247
Worm 222 ----------------------------CAAT------- 225
Yeast 87 --------------------------------------- 86
Arabidopsis 403 --------------------TGGCTT--AGA------TC 413
cons 1756 1794
Human 1682 GCTGTTT-CATTTGTCAGACTTCTTTTTGTCCCTCTTTA 1719
Chimpanzee 1533 GCTGTTT-CATTTGTCAGACTTCTTTTTGTCCCTCTTTA 1570
Rat 998 GTTGTTTTCCTGTGTAAATTTTTTGTTTTTGTCT-TTCT 1035
Mouse 1033 GTTGTTTTCCTGTGGAAGTTTTTTGTTTTTGTCT-TTTT 1070
Zebrafish 839 ATTGTTT-TA----------------ATTTG--TCTTTA 858
Fruitfly 248 --------------------------------------- 247
Worm 226 GTTGT---------------------------CT----- 232
Yeast 87 --------------------------------------- 86
Arabidopsis 414 GTTGAA------------TATCTGGTATATGTGT-T--- 436
cons 1795 1833
Human 1720 CTTCTCCCCAC-ATAATTCACCAGTACTAGTGTTTTGTT 1757
Chimpanzee 1571 CTTCTCCCCAC-ATAATTCACCAGTACTAGTGTTTTGTT 1608
Rat 1036 CTTCTTCCCAC-ATAATTCACT---------GTG----- 1059
Mouse 1071 CTCCTCCCCAC-GTAATTCACT---------GTG----- 1094
Zebrafish 859 GCCTTCCCTATAATAATTTAAT---------GTT----- 883
Fruitfly 248 --------------------------------------- 247
Worm 233 --------------------------------------- 232
Yeast 87 --------------------------------------- 86
Arabidopsis 437 ---CT-----T-ATAAT--------GGGA---------- 448
cons 1834 1872
Human 1758 TTTCAGACCAAGTC--TCGCTCTGTCGCCCA-GGCTGGA 1793
Chimpanzee 1609 TTTCAGACCAAGTC--TCGCTCTGTCGCCCA-GGCTGGA 1644
Rat 1060 AGACAGGGCTTTTCCCCCACCCTGAG---AA-AGCTGAA 1094
Mouse 1095 AGAAAGACGAAGTT--CGGCTGGGTCT--TACCCCTG-T 1128
Zebrafish 884 TAAATTGTGAAGTT--CTT---------------CTGT- 904
Fruitfly 248 -------------CACC---------------------- 251
Worm 233 -----------------------ATTT--CATC------ 240
Yeast 87 --------------------------------------- 86
Arabidopsis 449 ------------TT------------------------- 450
cons 1873 1911
Human 1794 GTGCAGTGGCGCGATCTCAGCTCACTGCAACCTCCGCCT 1832
Chimpanzee 1645 GTGCAGTGGCGCGATCTCGGCTCACTGCAACCTCCGCCT 1683
Rat 1095 GAC---TA------GCTAGGTCTACCCCAGTGTCCACCT 1124
Mouse 1129 GTG---TG----GGTTTCTG------TCATCTTCCACCA 1154
Zebrafish 905 -------------ATTTTATC---CAGCAG----CGC-- 921
Fruitfly 252 --------------------------------------- 251
Worm 241 TC-----------GCTC-----------------CACCT 251
Yeast 87 --------------------------------------- 86
Arabidopsis 451 ----AG------GATCT---------------------- 457
cons 1912 1950
Human 1833 CCCAGGTTCAAGCAATTCTCCTGCCTCAGCCTCCCGGGT 1871
Chimpanzee 1684 CCCAGGTTCAAGCAATTCTCCTGCCTCAGCCTCCTGGGT 1722
Rat 1125 ---------------------TCC---------CAGAGC 1133
Mouse 1155 ----------TGC------CATGC---------CAGAGC 1168
Zebrafish 922 ------TTCAAGTA--TCTGTTG------------AGGT 940
Fruitfly 252 --------------------------------------- 251
Worm 252 ---------------------TCT---------C----- 255
Yeast 87 --------------------------------------- 86
Arabidopsis 458 ---------------------------ATGTT--T-T-- 464
cons 1951 1989
Human 1872 AGCTGGGACTACAGGCGCGCGCCGCCACGCCTGGCTAAT 1910
Chimpanzee 1723 AGCTGGGACTACAGGCGCGCGCCGCCACGCCTGGCTAAT 1761
Rat 1134 AGCT----------------------------------- 1137
Mouse 1169 AGCT----------------------------------- 1172
Zebrafish 941 ----------AAA--------------------GTTAGT 949
Fruitfly 252 --------------------------------------- 251
Worm 256 --------------------------------------- 255
Yeast 87 --------------------------------------- 86
Arabidopsis 465 -GGTG-------------------C-------------- 469
cons 1990 2028
Human 1911 TTTTTATATTTTAGTAGAGACGGCGTTTCACCATGTTGG 1949
Chimpanzee 1762 TTTTTATATTTTAGTAGAGACGGCGTTTCACCATGTTGG 1800
Rat 1138 --------------------------------------- 1137
Mouse 1173 --------------------------------------- 1172
Zebrafish 950 --TGTATAT--TTGCATATTCAGTCTTTCTCCTTA---- 980
Fruitfly 252 --------------------------------------- 251
Worm 256 --------------------------------------- 255
Yeast 87 --------------------------------------- 86
Arabidopsis 470 -----GTA-------TTAAAGCTT--------------- 481
cons 2029 2067
Human 1950 CCAGGATGGTCTCGATCTGTTGACGTCGTGATCCACCCG 1988
Chimpanzee 1801 CCAGGATGGTCTCGATCTGTTCACGTCGTGATCTACCCG 1839
Rat 1138 --------------------------------------- 1137
Mouse 1173 --------------------------------------- 1172
Zebrafish 981 -----ATAAT-----------------ATA--------- 988
Fruitfly 252 --------------------------------------- 251
Worm 256 --------------------------------------- 255
Yeast 87 --------------------------------------- 86
Arabidopsis 482 --------------------------------------- 481
cons 2068 2106
Human 1989 CCTCGGCCTCCCAAAGTGCTGGGATTACAGGCGTGAGCC 2027
Chimpanzee 1840 CCTCGGCCTCCCAAAGTGCTGGGATTACAGGCGTGAGCC 1878
Rat 1138 --------------------------------------- 1137
Mouse 1173 --------------------------------------- 1172
Zebrafish 989 -ATTTC---ACCAAAGA----AAAT--CAATTA---AAA 1014
Fruitfly 252 --------------------------------------- 251
Worm 256 --------------------------------------- 255
Yeast 87 --------------------------------------- 86
Arabidopsis 482 ----------------------------AGTTG------ 486
cons 2107 2145
Human 2028 ACCCCGCCCGGCCACCAGTGCTATTCTTAAGACGCCTCT 2066
Chimpanzee 1879 ACCCCGCCCGGCCACCAGTGTTAGTCTTAAGACGCCTCT 1917
Rat 1138 --------------------------------------- 1137
Mouse 1173 ----C----G--------CACTATTTTTGTGACGCT--- 1192
Zebrafish 1015 TTCTAAA----TAGTAAATCATAT--------------- 1034
Fruitfly 252 --------------------------------------- 251
Worm 256 --------------------------------------- 255
Yeast 87 --------------------------------------- 86
Arabidopsis 487 ----AGA----TTGA---TGT----TTT----------- 499
cons 2146 2184
Human 2067 GAGGAATCCCTTCTCCCTGGCCATTGAGAATCCATGCAT 2105
Chimpanzee 1918 GAGGAATCCCTTCTCCCTGGCCGTTGAGAATCCATGCAT 1956
Rat 1138 --------------------------------------- 1137
Mouse 1193 -----------------------------------GCA- 1195
Zebrafish 1035 ----AATC------------------------------- 1038
Fruitfly 252 --------------------------------------- 251
Worm 256 --------------------------------------- 255
Yeast 87 --------------------------------------- 86
Arabidopsis 500 -----------------TGGGTTTTCAAATT-------- 513
cons 2185 2223
Human 2106 GAACCCAGGTT---------TTCCACCTTCCCTGAGCAG 2135
Chimpanzee 1957 GAACCCAGGTTTCTGTCATTTTCTACCTTCCCTGAGCAG 1995
Rat 1138 --------------------------------------- 1137
Mouse 1196 -AAC----------------------------------- 1198
Zebrafish 1039 ------------------------ACTTTCAAAGTAC-- 1051
Fruitfly 252 --------------------------------------- 251
Worm 256 --------------------------------------- 255
Yeast 87 --------------------------------------- 86
Arabidopsis 514 -----CTGTTT---------------------------- 519
cons 2224 2262
Human 2136 CTTGCATAGTTCCTTCTTTTAAGCGCCTGACTTCGTTTT 2174
Chimpanzee 1996 CTTGCATAGTTCCTTCTTTTAAGCGCCTGACTTCGTTTT 2034
Rat 1138 --TGCAGCATTC----TTTG------GTGAC-------- 1156
Mouse 1199 --TAC------------------------ACATCGC--- 1208
Zebrafish 1052 --AACATTGTTCA--CTATCAAACTA----T------TT 1076
Fruitfly 252 ---------------------------C----------- 252
Worm 256 --------------------------------------- 255
Yeast 87 --------------------------------------- 86
Arabidopsis 520 ------------CTTG-TCT------------------- 526
cons 2263 2301
Human 2175 GTTTGGTGC----CCGTTGTACCTGAGAATGAGCCTTGG 2209
Chimpanzee 2035 GTTTGGTGC----CCGTTGTACCTGAGAATGAGCCTTGG 2069
Rat 1157 ----GCTGC----CCTTTGTACCCG---ATCAAA---CG 1181
Mouse 1209 ---TGGTGC--C--CTTTGTACCCA---ATGAAA---CG 1234
Zebrafish 1077 -----GTGC--TAATGTTGT--TTTAAAGTTAAACTTGC 1106
Fruitfly 253 ----GCGGC----CCCCT--------------------- 262
Worm 256 --------------------------------------- 255
Yeast 87 --------------------------------------- 86
Arabidopsis 527 GTT----GAGCT-AATTTAA------------------- 541
cons 2302 2340
Human 2210 ATAGTGGAGCATTCCAGCTTTCCAGATATGCAGAGATAA 2248
Chimpanzee 2070 ATAGTGGAGCATTCCAGCTTTCCAGATATGCAGAGATAA 2108
Rat 1182 ATAGTTAAGCATTCCAGGTTGGCAGC--------TGTAA 1212
Mouse 1235 ATAGTTAAGCATTCCAGATTGGCAGT--------TGTAA 1265
Zebrafish 1107 ----------GTT----CATACCAAATATTGAAAGTAAA 1131
Fruitfly 263 ----------CTTCCA----------------------- 268
Worm 256 --------------------------------------- 255
Yeast 87 --------------------------------------- 86
Arabidopsis 542 ---------TGT---TG--TG------------------ 548
cons 2341 2379
Human 2249 TACATTGGCTATCAGCTACTTGGCTTGGCCTATTCCGTG 2287
Chimpanzee 2109 TACATTGGCTATAAACTACTTGGCTTGGCCTATTCCGTG 2147
Rat 1213 CAACTTGACTATCAAA--ACTG-TTTG-----------A 1237
Mouse 1266 -----------TCAA--AGCTG-GTTG-----------A 1279
Zebrafish 1132 AAAAT---AT----------------------------- 1138
Fruitfly 269 ---C----------------------------------- 269
Worm 256 --------------------------------------- 255
Yeast 87 --------------------------------------- 86
Arabidopsis 549 --------------------------------------- 548
cons 2380 2418
Human 2288 T-------------TTAAAATCTTGGACTCTTTGCTAGT 2313
Chimpanzee 2148 T-------------TTAAAATCTTGGACTC--TGCTAGT 2171
Rat 1238 T-------------TTAAA--------CTG-TTGCCAAC 1254
Mouse 1280 T-------------TTAAC--------CTG-TTGCCAAC 1296
Zebrafish 1139 ---------------AAAAATATAGGG------GGTATT 1156
Fruitfly 270 TTCAATATGCTGCTTTA---------------------- 286
Worm 256 --------------------------------------- 255
Yeast 87 --------------------------------------- 86
Arabidopsis 549 ----------------------TAGA------------- 552
cons 2419 2457
Human 2314 TTTTACAGATCA--------------------------- 2325
Chimpanzee 2172 TTTTACAAATCA--------------------------- 2183
Rat 1255 TTTTCAAAATCAGTTTTTTTCTACTCAAAGTTCCTAGTC 1293
Mouse 1297 TTTTCAGAATCAGAT-TTTTCTACCCAAAGTTCATATTC 1334
Zebrafish 1157 ---------TCA--------------------------- 1159
Fruitfly 287 ------AAT------------------------------ 289
Worm 256 --------------------------------------- 255
Yeast 87 --------------------------------------- 86
Arabidopsis 553 ----ACC-------------------------------- 555
cons 2458 2496
Human 2326 --------------------------------------- 2325
Chimpanzee 2184 --------------------------------------- 2183
Rat 1294 CCTTATTTTGTTGAAAACGTTGGAGAGTTAAAGTAGAAA 1332
Mouse 1335 CCTTATTCTGTTGCAAAAGTTGGACATTTAAAAAAAAAA 1373
Zebrafish 1160 --------------------------------------- 1159
Fruitfly 290 ------TCTGTCGA---------GCATTTTAAT----TA 309
Worm 256 ----TCTCTCTCT---------CTCGTGTTTAC----CA 277
Yeast 87 --------------------------------------- 86
Arabidopsis 556 --------------------------------------- 555
cons 2497 2535
Human 2326 --------------------------------------- 2325
Chimpanzee 2184 --------------------------------------- 2183
Rat 1333 GGTCC---------------------------------- 1337
Mouse 1374 AAACC---------------------------------- 1378
Zebrafish 1160 --------------------------------------- 1159
Fruitfly 310 AGTCC---------------------------------- 314
Worm 278 TTTCTTTTTTAATTTTGCATCTATCGACTGTGATCTGCC 316
Yeast 87 --------------------------------------- 86
Arabidopsis 556 --------------------------------------- 555
cons 2536 2574
Human 2326 --------------------------------------- 2325
Chimpanzee 2184 --------------------------------------- 2183
Rat 1338 -----------------GG--TATGAGTGTCCT-----T 1352
Mouse 1379 ----------------TAAAAAATGATTGTCCT-----T 1396
Zebrafish 1160 --------------------------------------- 1159
Fruitfly 315 -----------------GA--TTTGAGT----------- 323
Worm 317 TGTTTTTTTCTAATTCTAA--ACTTTTTGCCGTGATATT 353
Yeast 87 --------------------------------------- 86
Arabidopsis 556 --------------------------------------- 555
cons 2575 2613
Human 2326 -----------------------GAATTTTTCAC-G--- 2337
Chimpanzee 2184 -----------------------GAATTTTTCAC-G--- 2195
Rat 1353 GTTTGTTGCAGTTGGTTGCGTCTTGCCTTTTCTCCC--- 1388
Mouse 1397 GCTTGTTG--GTCGGTTGC-TCTTACATTTTCTCCC--- 1429
Zebrafish 1160 -----------------------TAAGTTTTCAC----- 1170
Fruitfly 324 ---------------TTACG-----CCTAGTCACCCAGC 342
Worm 354 C--CTTA-------------------------------- 358
Yeast 87 --------------------------------------- 86
Arabidopsis 556 -------------------------ATTTG--------- 560
cons 2614 2652
Human 2338 -----TA----TTAATCCAGTTTTCCTAGCTTCTCTT-G 2366
Chimpanzee 2196 -----TA----TTAATCCAGTTTTCCTAGCTTCTCTT-G 2224
Rat 1389 ---------TGTTGCTACAATTTCTGAAGTAATACTAAA 1418
Mouse 1430 -----TA----TTGCTACACTTTCTGGAGCAGTACTA-A 1458
Zebrafish 1171 -----------------------------------TG-A 1173
Fruitfly 343 AAGTGCACCTTTAT---ATTTATAT-----AAGCCGCAC 373
Worm 359 --------------------------GA----------- 360
Yeast 87 --------------------------------------- 86
Arabidopsis 561 ----------------TTTTTTTCTGGAT---------- 573
cons 2653 2691
Human 2367 ---A-AGAATTTTTGGAGATCTCTTCATACTGAGCCTTC 2401
Chimpanzee 2225 ---A-AGAATTTTTGGAGATCTCTTCATACTGAGCCTTC 2259
Rat 1419 ---TTTGAATTTTGGATGTTCTTTTCTTTTTT---GTTA 1451
Mouse 1459 ---TTTGAATTTTGGGTGTTCTTTTCTTTTTT---GTTA 1491
Zebrafish 1174 ---A-TGAATGTGCG--GATGT---AA-----AACCAAC 1198
Fruitfly 374 CAAAATGCGCAT---ATGT-------------------- 389
Worm 361 ---------------GTGTTC----CC------------ 368
Yeast 87 --------------------------------------- 86
Arabidopsis 574 --------------------CTTTACTTATT-------T 585
cons 2692 2730
Human 2402 ATTAGCCC-------------------AGGACAGTACTG 2421
Chimpanzee 2260 ATTAGCCC-------------------AGGACAGTACTG 2279
Rat 1452 AGTAGCAAATTCTCTA-------GATTTGGATG------ 1477
Mouse 1492 AGTGGCAAATTTTCTA-------GATTTGGATA------ 1517
Zebrafish 1199 TTTACCTC-------------------AATCAAGTATT- 1217
Fruitfly 390 ------------------------G-------------- 390
Worm 369 --------------TAGAAAATTCGT------------- 380
Yeast 87 --------------------------------------- 86
Arabidopsis 586 GTA------------------------------------ 588
cons 2731 2769
Human 2422 CTGTAGCAGTTCATATATTTTTTCGCTTC---------- 2450
Chimpanzee 2280 CTGTAGCAGTTCATATATTTTTTCGCTTC---------- 2308
Rat 1478 ------------------------CCTAATGAGACTTTT 1492
Mouse 1518 ------------------------GCTAATGAGATTTTT 1532
Zebrafish 1218 -----------CA-ATATGTCAT---------------- 1228
Fruitfly 391 --------------------------------TGTG--- 394
Worm 381 -----------------------------TG------AA 384
Yeast 87 --------------------------------------- 86
Arabidopsis 589 -------------TAT----------------------- 591
cons 2770 2808
Human 2451 --------CCAGGCCTGTGT---TATTCACTTAAGT--- 2475
Chimpanzee 2309 --------CCAGGCCTGTGT---TATTCACTTAAGT--- 2333
Rat 1493 -TTAAAAAGTAGCTCTG-GT---TAG--ACCCAAAT--- 1521
Mouse 1533 TTTTTAAGGTAGCTCTG-GT---TA--GACCCAAAT--- 1562
Zebrafish 1229 --------CGAGGCATGTTT---TGATTTTTTAAAT--- 1253
Fruitfly 395 -------------------------C--GCTCAAGT--- 403
Worm 385 TTT-------------------------A---------- 388
Yeast 87 --------------------------------------- 86
Arabidopsis 592 ----------------GTATTGGTTTATGTTTATGTTTT 614
cons 2809 2847
Human 2476 ---TCATAGCCTGGTCCCT--GCAGGGTTGTACCCGAGC 2509
Chimpanzee 2334 ---TCATAGCCTGGTCCCT--GTAGGGTTGTACCCAAGC 2367
Rat 1522 -----------GGATCCC--CACAGG-CAGTAG---GAC 1543
Mouse 1563 ---G--------GATCTCC--ACAGG-CAGTAG---GAC 1584
Zebrafish 1254 ---TTATTT-----------------TTTTTA------- 1265
Fruitfly 404 -----------G-CCTACAGCAAAGG-TC---------- 419
Worm 389 ----------------------CAGG------T-----C 394
Yeast 87 --------------------------------------- 86
Arabidopsis 615 TACA--------GATC-----A------------CAA-- 626
cons 2848 2886
Human 2510 ACAGCTACTTAGATGTCCTGAATGTATTACCGGTTAAAT 2548
Chimpanzee 2368 ACAGCTACTTACATGTCCCGAGTGTATTACCAGTTAAAT 2406
Rat 1544 ACAATTATTTTCT-GG--CTACTGGATAA------AATT 1573
Mouse 1585 AAAGGCATTTTCT-GA--CCACTAAATAA------AAAT 1614
Zebrafish 1266 ----TTACTC---------AAATCTATTA------AAA- 1284
Fruitfly 420 ---------------A--C----G---AA------AT-- 426
Worm 395 GAAGCCG--------------CTCA--AA------AAAT 411
Yeast 87 --------------------------------------- 86
Arabidopsis 627 --AGGC----------------CAAGTAA------CAAT 641
cons 2887 2925
Human 2549 GGAGGTTTCAAAGAACCTGCTGTTTTTGGCCCTGTGCTC 2587
Chimpanzee 2407 GGAGGTTTCAAAGAACCTGCTGTTTTTGGCCCTGTGCTC 2445
Rat 1574 ATGGG--------AA-CTGATAAAC--ATCACTGA-ATG 1600
Mouse 1615 AGGG-----G---AA-CTGATAAA---ATCACTGA-ATG 1640
Zebrafish 1285 -CAAGTTTCAT-GAT------CTTTTCTTCCATAT---T 1312
Fruitfly 427 -TG---------------------G-------------- 429
Worm 412 GTCG-----A---AC------------------------ 418
Yeast 87 --------------------------------------- 86
Arabidopsis 642 GGCG-----A---AA------------------------ 648
cons 2926 2964
Human 2588 TTGATAACAGAGTGTTTGAGGGACAACTTTCACATTTGA 2626
Chimpanzee 2446 TTGATAACAGAGTGTTTGAGGGACAACTTTCACATTTGA 2484
Rat 1601 TGGAGTAGAGGTTTCTG----GGCAGCC---A-----AT 1627
Mouse 1641 TGGAGAACAGGGTTCTC----GGCAGCC---A-----GT 1667
Zebrafish 1313 T---TAAT-G--------------------TATATCTGA 1327
Fruitfly 430 -----TACTGGACA-TA----AAAAGG----A-----GT 449
Worm 419 -CG------------------------------------ 420
Yeast 87 --------------------------------------- 86
Arabidopsis 649 -GGAGTTGCA-GTTTTG----AACAGC----A-----GT 672
cons 2965 3003
Human 2627 GTTTTTCCAAAATTAAAGGTTGT--AGAAGAGTCACAGT 2663
Chimpanzee 2485 GTTTTTCCAAAATTAAAGGTTAT--AGAAGAGTCACAGT 2521
Rat 1628 GTTCTGAAAGAATCAAGCCTGACACAGTGCAGTAGC--C 1664
Mouse 1668 GTTCTGTAAGAGTCAAGTCTGAC--AGTGCAGTAG--CC 1702
Zebrafish 1328 GT------AAA----ATGTCTGT--AACGAGGACAAA-- 1352
Fruitfly 450 -----TAAGA----------------------------- 454
Worm 421 ---------------------------TGC--------- 423
Yeast 87 --------------------------------------- 86
Arabidopsis 673 G-------AGG-----GTGTTAC--GGGG-------ACT 690
cons 3004 3042
Human 2664 ATCTATTGTCAA-AAAGAAAAGAATTTAAAAAGGCAGCA 2701
Chimpanzee 2522 ATCTATTGTCAA-AAAGAAAAGAATTTAAAAAGGCAGCA 2559
Rat 1665 ATCCATTCCCTA---GTTCTGACATTGA-GCTGCC---- 1695
Mouse 1703 ATCTCTTCCCCA---GGCCTGGCATTCA-GTAGCC---- 1733
Zebrafish 1353 ------GGTTGA-AGAGTAAAAAATTTTTT--------T 1376
Fruitfly 455 --------------------------------------- 454
Worm 424 -------------------------------TG------ 425
Yeast 87 --------------------------------------- 86
Arabidopsis 691 ATCTTTT-TCACCCAG-------------GAAGGC---- 711
cons 3043 3081
Human 2702 ATTGCCAGGATACTTCATTTGAGCAATGATATTTTCCAG 2740
Chimpanzee 2560 ATTGCCAGGATACTTCATTTGAAAAATGGTATTTTCCAG 2598
Rat 1696 -----CCCTTTTGTTCC------TCTGGGTGCTTTTCAA 1723
Mouse 1734 -----CCTGTTTGTTCC------ACCTGGTGCTTTCTAA 1761
Zebrafish 1377 TTTTCCATGA--ATTGATTTGAATGTTGTGGTTTTCTAT 1413
Fruitfly 455 -----------TAT------------------------- 457
Worm 426 --------------------------------------- 425
Yeast 87 --------------------------------------- 86
Arabidopsis 712 -----GATGGTAGTTC----------------TTTAT-- 727
cons 3082 3120
Human 2741 TGGAAAGTCACATCTTAAGGGTTAATGCCCCTTAACTGT 2779
Chimpanzee 2599 TGGAAAGTCACATCTTAAGGGTTAATGCCTCTTAACTGT 2637
Rat 1724 GTGCT--------GTTGAGTCCAGGTGTCTG--CACACG 1752
Mouse 1762 ATGCT--------GTTCAGTCCAGGTGCCTG--CACACA 1790
Zebrafish 1414 TAG----TT-GAGCTT--GGGTGAT----TTATGACT-- 1439
Fruitfly 458 --------------------------------------- 457
Worm 426 --------------------------------------- 425
Yeast 87 --------------------------------------- 86
Arabidopsis 728 ----------------AAGAG----TGCTTT-------- 738
cons 3121 3159
Human 2780 TGGCCGTATTTGAAAACAAACCAAGCTAAAAACAAGAGA 2818
Chimpanzee 2638 TGGCCGTATTTGAAAACAAACCAAGCTAAAAACAAGAGA 2676
Rat 1753 T-G---CATCTG----------------GAAACAAGTGT 1771
Mouse 1791 TGG---CATCTG----------------GCAGCAAGTGT 1810
Zebrafish 1440 ----TGTATT-G---ATAAACCTCTCATAAAATAAGTGA 1470
Fruitfly 458 --------------------------------------- 457
Worm 426 --------------------------------------- 425
Yeast 87 --------------------------------------- 86
Arabidopsis 739 ---------------------------ATA----AGA-- 744
cons 3160 3198
Human 2819 CA--------CTGACATGTTGTATGACGGTGTGGTGTGG 2849
Chimpanzee 2677 CA--------CTGACATGTTGTATGACGGTGTGGTGTGG 2707
Rat 1772 TAGGGAAGATG-GGTAGGGAGGGAGA------GGCCTAG 1803
Mouse 1811 TAGGAGAAGTGTGACAGGGAGAGAGA------GGCCTAG 1843
Zebrafish 1471 CA--------TT--------GCAAGAAAGCAAAATAAGC 1493
Fruitfly 458 -------------------------------------AA 459
Worm 426 --------------------------------------- 425
Yeast 87 --------------------------------------- 86
Arabidopsis 745 ----------------TCT---TTGAA------GCCTA- 757
cons 3199 3237
Human 2850 ATGTTGTGTTTATTTTAGTCCTGAGATCTAGTTGTAACT 2888
Chimpanzee 2708 ATGTTGTGTTTATTTTAGTCCTGAGATCTAGTTGTAACT 2746
Rat 1804 AG-CTAAGCAGC-TCT----------------------- 1817
Mouse 1844 AG-CTGAGCGTC-TCC----------------------- 1857
Zebrafish 1494 ATATTGTCA--CTTTTGATTCCGTGT-TGAGATA-AAC- 1527
Fruitfly 460 AG-C----------------------------------- 462
Worm 426 --------------------------------------- 425
Yeast 87 --------------------------------------- 86
Arabidopsis 758 -T-----CTTT--TTT----------------------T 766
cons 3238 3276
Human 2889 TCCTTGATTTCTGTATGTAGCCAC-------------GG 2914
Chimpanzee 2747 TCCTTGATTTCTGTATGTAGCCAC-------------GG 2772
Rat 1818 ----AGA---------GTCACCCT-------------GG 1830
Mouse 1858 ----AGA---------GCCACCCT-------------GT 1870
Zebrafish 1528 ----------------------ATGCAGTGCATTCCAGG 1544
Fruitfly 463 --------------------------------------- 462
Worm 426 --------------------------------------- 425
Yeast 87 --------------------------------------- 86
Arabidopsis 767 TCCTT---------------------------------- 771
cons 3277 3315
Human 2915 AGCACC----ATTA------------------------- 2924
Chimpanzee 2773 AGCAAC----ATTA------------------------- 2782
Rat 1831 AGGAAATGGGTCTA------------------------- 1844
Mouse 1871 AGGAAGTGGGTCTA------------------------- 1884
Zebrafish 1545 TGTAC-----ATTTGGAAACAAATTGTCTGTATGATGTG 1578
Fruitfly 463 -----------TCA------------------------- 465
Worm 426 --------------------------------------- 425
Yeast 87 --------------------------------------- 86
Arabidopsis 772 --------------------------------------- 771
cons 3316 3354
Human 2925 -CCTGTCACCATTACCTGAATGGCTATACTGCTT-GCTT 2961
Chimpanzee 2783 -CCTGTCACCATTACCTGAATGGCGATACTGCTT-ACTT 2819
Rat 1845 -CTTGG-------ATTTGGA----CATAG-GTTTGATT- 1869
Mouse 1885 -CTTGG-------ATCTGAA----CATAG-GTTTGATTT 1910
Zebrafish 1579 TTTTG-------CAGCCAAG----CATAA-CTTGGTTAA 1605
Fruitfly 466 -CTTG--------TTCGT--------------------- 474
Worm 426 --------------------------------------- 425
Yeast 87 --------------------------------------- 86
Arabidopsis 772 -CCTCTCA----------A--------ATGA-------- 783
cons 3355 3393
Human 2962 TCATTTTGGTAGAGTGGAAAGGTTACCTAGGTTTCAGTG 3000
Chimpanzee 2820 TCATTTTGGTAGAGTGGAAAGGTTACCTAGGTTTCAGTG 2858
Rat 1870 TTGTTTTG----TTTTTTGACTTGTGCCT-TTTACTGTG 1903
Mouse 1911 TCACTGTTGTG-TGTTTTGACTTGAGCTT-TTTACTGTG 1947
Zebrafish 1606 CTGCGCTTTTG-TTTTGTGAAATGATAT--GAAACCATG 1641
Fruitfly 475 -------------------------------AAAGTATC 482
Worm 426 TCGCTG--------------------------------- 431
Yeast 87 --------------------------------------- 86
Arabidopsis 784 --------------------------------------- 783
cons 3394 3432
Human 3001 CTTGAAAAGATTTCAGAAAG---CAGTA-GTACGTCTG- 3034
Chimpanzee 2859 CTTGAAAAGATTTCAGAAAG---CAGTA-GTACCTCTG- 2892
Rat 1904 ---------A-TT----------CAGA------------ 1910
Mouse 1948 CTTGGTTAGGGTGT--AACC---CAGCA-ACAGCCCTGG 1980
Zebrafish 1642 TTTTCTGAAGT---GATATGAAACCGTTGTTAAC----- 1672
Fruitfly 483 ---------G-T-------------TA------------ 486
Worm 432 --------------------------------------- 431
Yeast 87 --------------------------------------- 86
Arabidopsis 784 --------------------------------------- 783
cons 3433 3471
Human 3035 ----------------GTTAGACTAGAATCAGTCCTCTC 3057
Chimpanzee 2893 ----------------GTTAGACTAGAATCAGTCCTCTC 2915
Rat 1911 ------AGTATTAA--CACAAACTTGAT---GTCTTA-- 1936
Mouse 1981 TGCAGGAGTATTTACACTCAAACTTGAT---GTCTTC-- 2014
Zebrafish 1673 ----------------CACACAATGGA------------ 1683
Fruitfly 487 ------AATATCAA--CA--AA----------------- 498
Worm 432 ------TTCTTCGTGGA-GAAAC---------------- 447
Yeast 87 --------------------------------------- 86
Arabidopsis 784 -----------------------TTGAG---TTCTTT-- 794
cons 3472 3510
Human 3058 CTGGGGGCAGTGGAATATAATATTTTCTGACTGCTAATT 3096
Chimpanzee 2916 CTGGGGGCCGTGGAATAGAATATTTTCTGACTGCTAATT 2954
Rat 1937 -------------ATTTTTGTATTTTTTTA-----AATA 1957
Mouse 2015 -------------ATTTTTGTATTTTTTTA-----AATC 2035
Zebrafish 1684 --------------TCT--GTATGTTTTAG-----GGTG 1701
Fruitfly 499 --------------TATTTG----TTTTAG-----AA-- 512
Worm 448 ------------------TG----TT------------- 451
Yeast 87 --------------------------------------- 86
Arabidopsis 795 -------------GTTTGGG--TTTTTT----------- 807
cons 3511 3549
Human 3097 AAAAATACCTGTGATAGCCGGGCGTGGTGGCTTACGCCT 3135
Chimpanzee 2955 AAAAATACCTGTGATAGCCGGGTGTGGTGGCTCACACCT 2993
Rat 1958 AAGGCAAGCGGTG--AACCAGTTGTGGTGTC--AGGAC- 1991
Mouse 2036 AAGGCAAGCGGTG--AACCAGTTGTGTTGTC--AGGAC- 2069
Zebrafish 1702 AAAAG-------A--AGCCAGTCAAGGTGAC--TGGTG- 1728
Fruitfly 513 ----TAAGC------------------------------ 517
Worm 452 ------ACCGGT--------------------------- 457
Yeast 87 --------------------------------------- 86
Arabidopsis 808 ---GCAGG-TGTG--A-CCAC-TGTG---AGT-GGAAC- 833
cons 3550 3588
Human 3136 GTAATCCCAGCACT-TT-GGGAGGCCGAGACGGGTGGAT 3172
Chimpanzee 2994 GTAATCCCAGCACT-TT-GGGAGGCCGAGACGGGTGGAT 3030
Rat 1992 -AGATTACAGGATT-AACTGAAGGCGAGCATGG----GT 2024
Mouse 2070 -AAATTACAGGATT-AACTGAAGGCCAGCATGG----GT 2102
Zebrafish 1729 -AAATTACTGGCCT-TACTCCAGGAAAACATGG----TT 1761
Fruitfly 518 ---AT--------T-A------GG--------------- 523
Worm 458 -----------ACT-ATCT---GG--------------- 466
Yeast 87 --------------------------------------- 86
Arabidopsis 834 -AG-TTTCTGGCCTTAA-GCCTGGTCTTCATGG----TT 865
cons 3589 3627
Human 3173 CACGAG--------------------------------- 3178
Chimpanzee 3031 CACGAG--------------------------------- 3036
Rat 2025 TCCATG--------------------------------- 2030
Mouse 2103 TCCACG--------------------------------- 2108
Zebrafish 1762 TCCACG--------------------------------- 1767
Fruitfly 524 --------------------------------------- 523
Worm 467 --------------------------------------- 466
Yeast 87 -----CACTGTCTCTTACGAGATCGCTGGTAACAGTCCT 120
Arabidopsis 866 TCCATG--------------------------------- 871
cons 3628 3666
Human 3179 ----------------------GTCAGCAGATGGAGACC 3195
Chimpanzee 3037 ----------------------GTCAGCAGATCAAGACC 3053
Rat 2031 ----------------------TCCATCAA--------- 2038
Mouse 2109 ----------------------TCCATCAG--------- 2116
Zebrafish 1768 ----------------------TCCATGCT--------- 1775
Fruitfly 524 ----------------------------AA--------- 525
Worm 467 --------------------------------------- 466
Yeast 121 AACGCAGAACGTGGGTTCCACATTCATGAG--------- 150
Arabidopsis 872 ----------------------TCCATGCT--------- 879
cons 3667 3705
Human 3196 ATCCTGGCTAACACGGTGAAACCCCGTCTCTACTAAAAA 3234
Chimpanzee 3054 ATCCTGGCTAACACGGTGAAACCCCGTCTCTACTAAAAA 3092
Rat 2039 -----------TATGGGGAC-----------------AA 2049
Mouse 2117 -----------TATGGGGAC-----------------AA 2127
Zebrafish 1776 -----------TTTGGTGAC-----------------AA 1786
Fruitfly 526 -----------TATGGGAAT-----------------AA 536
Worm 467 ------------------AT------------------- 468
Yeast 151 -----------TTTGGAGAT-----------------GC 161
Arabidopsis 880 -----------CTTGGTGAC-----------------AC 890
cons 3706 * 3744
Human 3235 TGCAAAAAAATTAGCCGGGTGTGGTGG-T--------G- 3263
Chimpanzee 3093 TACAAAAAAATTAGCCGGGTGTGGTGG-C--------G- 3121
Rat 2050 TACAC--AA--------GGT-----A-AGTCTTAATCTA 2072
Mouse 2128 TACAC--AA--------GGT-----A-GGTCCTAGGCTG 2150
Zebrafish 1787 CACAA--AC--------GGT-----AA-GGAGTGGTCAA 1809
Fruitfly 537 T-------------------------------TAG---- 540
Worm 469 CACAC--A---------GGT-----TAGC---------- 481
Yeast 162 CACCA--AT--------GGT-----TG-T---------G 175
Arabidopsis 891 CACTA--AC--------GGT-----TG-C---------- 903
cons 3745 3783
Human 3264 GG------CGCCTGTAGTCCCAGCTAC------TCAGGA 3290
Chimpanzee 3122 GG------CGCCTGTAGTCCCAGCTAC------TCAGGA 3148
Rat 2073 TCTCTACCTGGCTGA----C----TAGTGAGATGAATGG 2103
Mouse 2151 GC------TA-GTGA--------CCAGTGATGGAAAGGA 2174
Zebrafish 1810 AC------TGAACAT--------TTAGCGATTATTATGG 1834
Fruitfly 541 -------------------------AATG--AT------ 546
Worm 482 --------------------------------------- 481
Yeast 176 ------------TCT--------CT-------------- 180
Arabidopsis 904 -----------ATGT--------CTAC------------ 911
cons 3784 3822
Human 3291 GGCTGAGGCAGGAGAATGGCATGAACCTGGGAGGCGGAG 3329
Chimpanzee 3149 GGCTGAGGCAGGAGAATGGCATGAACCTGGGAGGCGGAG 3187
Rat 2104 GACTGAGTCAGGACC-AATTACTAACCATTTAAA----A 2137
Mouse 2175 -ACTGAGTCAGGACCCAATTACTAACCATTTAAA----A 2208
Zebrafish 1835 -CCCACATGATGAT-----TTATATCGCTTCATT----T 1863
Fruitfly 547 -GCT-----------------------GTTCATA----A 557
Worm 482 ---CGAGT--------------TTTCCGCTTAAA----- 498
Yeast 181 --------------------------------------- 180
Arabidopsis 912 ---TG-------------G---TAAC-TCTTATG----- 925
cons 3823 3861
Human 3330 CTTGCAGTGAGCCGAGATCATGTCACTGCACTCCAGCCT 3368
Chimpanzee 3188 CTTGCAGTGAGCCGAGATCATGTCACTGCACTCCAGCCT 3226
Rat 2138 C--------------CATCAATTTTTTTCTT--T-TTCT 2159
Mouse 2209 C------------TATCTCGTTTGTTTTCTT--T-TTCT 2232
Zebrafish 1864 C------------TCCCCCCATTTTGTGCAT--T-CACC 1887
Fruitfly 558 T-----------------TAATTT-GT------------ 566
Worm 499 -----------------TCATTTGTATTCTT--T-TT-- 515
Yeast 181 --------------------------------------- 180
Arabidopsis 926 ------------------C----------ATACCTCTCT 936
cons 3862 3900
Human 3369 GGGCGACAGAGCGAGACTCGTCTCAAAAAAAAAAAGAAA 3407
Chimpanzee 3227 GGGTGACAGAGCGAGACTCGTCTCAAAAA---AAAGAAA 3262
Rat 2160 TTTAGATTAAG---------------------------- 2170
Mouse 2233 TTTAGATAAAG---------------------------- 2243
Zebrafish 1888 ACCCTATTAAA---------------------------- 1898
Fruitfly 567 ---ACATCAA----------------------------- 573
Worm 516 --CAGA---AG---------------------------- 521
Yeast 181 --------------------------------------- 180
Arabidopsis 937 G-----CAA------------------------------ 940
cons 3901 3939
Human 3408 AAAACTTATGATGGACACTTAAAA--ACACTC------- 3437
Chimpanzee 3263 AAAACTTATGATGGACACTTAAAA--ACACT-------- 3291
Rat 2171 -----TTAAAATAACCACTTAGGTCAACCT-CGGAAAAT 2203
Mouse 2244 -----TTAAAATGACCACTTAGGTCAACCT-TGGAAAGT 2276
Zebrafish 1899 ------TGAGATCCCAGGTGTAAACAACCT-CCTTG-TG 1929
Fruitfly 574 ---------------------AGTCA---------AAGC 582
Worm 522 -----------------------------T-CCGAAAAT 530
Yeast 181 --------------------------------------- 180
Arabidopsis 941 ---ATTTTCAATGGA---TTAGAA--ACTTTTGGA---- 967
cons 3940 3978
Human 3438 -----------------ACTGA-GTGGGGAGTGGAGAGC 3458
Chimpanzee 3292 ----------------CACTGA-GTGGGGAGTGGAGAGC 3313
Rat 2204 AGCCACAAAAGTATTTTAGTTA-GTATCGAGT--ATTTC 2239
Mouse 2277 AGCCACAAAAGTATTTTATTTA-GTATCAAGT--ATTGC 2312
Zebrafish 1930 AGCA--AAATGCA--TCA--TA-ATTTCAGGT--GTAAA 1959
Fruitfly 583 AGC---A----------------ATGTCAAGT--GT--- 597
Worm 531 GACC----------------------------------A 535
Yeast 181 --------------------------------------- 180
Arabidopsis 968 -GCT--------T--ATATTTATGTTTC--GT--ATTGG 991
cons 3979 4017
Human 3459 A--------GGGGTCCCAGGGTAGCCTGTTGGAC-ATT- 3487
Chimpanzee 3314 A--------GGGGTCCCAGGGTAGCCTGTTGGAC-ATT- 3342
Rat 2240 T--------TGACTCCTTAAG-------TGGGAAGGT-- 2261
Mouse 2313 --------TTGCTTCCTTAAG-----TGTGGGAAGGTA- 2337
Zebrafish 1960 C--------GGGGTGTCAGGG-----TATGCCACTCCAT 1985
Fruitfly 598 -----------------CAA------------------- 600
Worm 536 GGCAGTTATTG---------------------AAGGAG- 552
Yeast 181 --------------------------------------- 180
Arabidopsis 992 G--------AACT---TTAAT-----TATCGCCA---A- 1010
cons 4018 4056
Human 3488 --TCCAGGGCGACTTTTTCTTTTTTTTTTTTTAAAGTC- 3523
Chimpanzee 3343 --TCCAGGGCGACTTTTTCTTTT----TTTTTAAAGTC- 3374
Rat 2262 ----GAGGGTAAAT-TTTCTTAA-----ATGTGATTATT 2290
Mouse 2338 --AAGAAGGTGATT-TTTCTTCA-----TTGTAATTAT- 2367
Zebrafish 1986 TCATTAAAGCA-GTGTTT-TT------------------ 2004
Fruitfly 601 --------GTAAA------------------CGATTATA 613
Worm 553 --------------------------------------- 552
Yeast 181 --------------------------------------- 180
Arabidopsis 1011 --AAGTAACTGAAC----------------TTG------ 1025
cons 4057 4095
Human 3524 --AA-GTGAGTATGCCATAT----GG-AAAAGGGTGTGC 3554
Chimpanzee 3375 --AA-GTGAGTATGCCATAT----GG-AAAAGGGTGTGT 3405
Rat 2291 ATAGCTTGACTTTAATATAC----AG---AAAC------ 2316
Mouse 2368 --AA-TTAAGC----------------AGCAC--C---- 2381
Zebrafish 2005 ------CAACCA--CGTTCC----AGGAGGAT--C---- 2025
Fruitfly 614 A-------ACTT-------------G------------- 619
Worm 553 --------------------------------------- 552
Yeast 181 --------------------------------------- 180
Arabidopsis 1026 ------TTATTA-------AATTCC-------------- 1037
cons 4096 4134
Human 3555 GTGGAGAAAAAGCAAGGGGCTCCA-GAGTGTAGGATGAG 3592
Chimpanzee 3406 GTGGAGAAAAAGCAAGGGGCTCCA-GAGTGTAGGATGAG 3443
Rat 2317 -----AAATACGC---ACCTTCC--TTATTTTGGATAA- 2344
Mouse 2382 ---------TTGC-TTATTCTGGGTGTTTATTGGGTGC- 2409
Zebrafish 2026 ---------AT---CAGTTCTGC--ATATTTTCCATGT- 2049
Fruitfly 620 ----------------------------------ATGA- 623
Worm 553 ------------A--AA-TCAAGGGACTTA--------- 567
Yeast 181 --------------------------------------- 180
Arabidopsis 1038 --------------------------TATTTTAGGTCCA 1050
cons 4135 4173
Human 3593 -ACATACA-CCTTTTGGGT---TAAAAAGGCTGAGGCAG 3626
Chimpanzee 3444 -ACATACA-CCTTTTGGGT---TAAAAAGGCTGAGGCAG 3477
Rat 2345 -------T-CCTTTGAGGT---GTTTGGAGCTGGGGGTT 2372
Mouse 2410 -------T-TATTT-GGGT---GTTTGGAGCTGGGCGTT 2436
Zebrafish 2050 -------C-TCCTT-AACC---AAACACACCTGA---TT 2073
Fruitfly 624 -----------TTACAGGTTATGTTT------------- 638
Worm 568 ----------------------CTCC------------- 571
Yeast 181 --------------------------------------- 180
Arabidopsis 1051 CAT-TTCAACCCC-GATGG------TAAAACACACG--- 1078
cons 4174 4212
Human 3627 GAGAATGGCGTGAACCCGGGAGGCGGAGCTTGCAGTGAG 3665
Chimpanzee 3478 GAGAATGGCGTGAACCCGGGAGGCAGAGCTTGCAGTGAG 3516
Rat 2373 GAGGGTGG-GTG----CTTTAGGCACAGTGTCT------ 2400
Mouse 2437 GAGGATGG-ATG----CATTAGGCAGAGTGTCT------ 2464
Zebrafish 2074 CAGATCAT-CAG----CTCCAGGAACATGGT-T------ 2100
Fruitfly 639 -------------------------CAGTG--------- 643
Worm 572 -------------------------CGGTCTT------- 578
Yeast 181 --------------------------------------- 180
Arabidopsis 1079 --------------------------------------- 1078
cons 4213 4251
Human 3666 CTGAGATCATGCCACTGCACTCCAGCCTGGGCGACAGAG 3704
Chimpanzee 3517 CTGAGATCATGCCACTGCACTCAAGCCTGGGTGACAGAG 3555
Rat 2401 --AAGGACA-GCT-ATGC--------ACGAGAGGCATAG 2427
Mouse 2465 --AAGGACA-ACC-ATGCC--TTAGCATGAGAGGCATAG 2497
Zebrafish 2101 --GAGA--A-ACA-CTGCA--TTAA-AGTACAAGTTCAT 2130
Fruitfly 644 -----------CC---------------G--AG------ 648
Worm 579 ----------------------------C--AT------ 581
Yeast 181 --------------------------------------- 180
Arabidopsis 1079 --------------GTGC--------------------- 1082
cons 4252 4290
Human 3705 CGAGACTCTTGTCTCAAAATAAAAAACGTTTACATGTAC 3743
Chimpanzee 3556 CGAGACTC-TGTCTCAGAATAAACAAA--AAAGGTTTAC 3591
Rat 2428 TGGGA---------CAGAAGTGACAAA--AAC------- 2448
Mouse 2498 CGGGA---------CAGAAGTGACAAA--AAC------- 2518
Zebrafish 2131 CCC------------ATCAGGACCAAT--AA-------- 2147
Fruitfly 649 ----------------GA-----------AAT------- 653
Worm 582 ----------------GG--------------------- 583
Yeast 181 --------------------------------------- 180
Arabidopsis 1083 -----------------------C------C-------- 1084
cons 4291 4329
Human 3744 ATGTATATTCA-ACATGTACAAATATAACCTATTCAAAA 3781
Chimpanzee 3592 ATGTATATTCA-ACATGTACAAATGTGGCCTATTCAAAA 3629
Rat 2449 -TGAAGATTCA-AT----ATAAATGC---TT-----AGA 2473
Mouse 2519 -TGAAGATTCA-AT----ATAAATGC---TT-----A-A 2542
Zebrafish 2148 CC-TTGACC------T---AAAACCA---TT-----AGA 2168
Fruitfly 654 -TT-----------------A--TG-------------- 658
Worm 584 ------ATTCC-A----------CGT------------- 592
Yeast 181 --------------------------------------- 180
Arabidopsis 1085 CTGAGGATGCTAA----TCGACATGCT------------ 1107
cons 4330 4368
Human 3782 GTATTTACTACATAAATAGGTACTTACATTACCTATTTA 3820
Chimpanzee 3630 GT----ACTACATAAATAGGTACTTACATTACCTATTTA 3664
Rat 2474 GT----A------AA------ATTTT----TTATATTTG 2492
Mouse 2543 GT----A------AG------ATTTATTTTCTCTATTTG 2565
Zebrafish 2169 C-----T------CC------ATTTT----T--TACCTG 2184
Fruitfly 659 ------------------------TT----TT------- 662
Worm 593 ---------------------------TCA--------- 595
Yeast 181 --------------------------------------- 180
Arabidopsis 1108 --------------------------------------- 1107
cons 4369 4407
Human 3821 CTGTAATAGTC-AAAGCCTATGAAGTATCTAACACTGAT 3858
Chimpanzee 3665 CTGTAATAGTC-AAAGCCTATGAAGTATCTAACACTGAT 3702
Rat 2493 GGATTGGAATC-AA-GTC-A----GAA-----------A 2513
Mouse 2566 GGATTAGAATC-AA-GTC-----AGTA---A-------A 2587
Zebrafish 2185 GTTCT-GAATCCAAAGTG----AA-GG-----------A 2206
Fruitfly 663 ------TAATC-TA----------TAA-----------A 673
Worm 596 -----CCAA------------------------------ 599
Yeast 181 --------------------------------------- 180
Arabidopsis 1108 -GGTG---ATC---------------------------- 1114
cons 4408 4446
Human 3859 GTGTA-------GGTACTCACTTTGCTTGCCACTCTATT 3890
Chimpanzee 3703 GTGTA-------GGTACTCACTTTGCTTGCCACTCTATT 3734
Rat 2514 ATATA-------GTGG----CTTACATTGC-A----TTT 2536
Mouse 2588 AAGTA-------GTGG----CTTAAATTGC-A----GTT 2610
Zebrafish 2207 GTAA--------ACAG---CTCTGAAAAGT-----TTTT 2229
Fruitfly 674 G-ATAACCAAATGT-------TTACTTTGC-T------- 696
Worm 600 -TATG-------GTG----------ATTC---------- 610
Yeast 181 --------------------------------------- 180
Arabidopsis 1115 -----------------------------------TA-- 1116
cons 4447 4485
Human 3891 AGGTGCTTTTTA----TGTTATTTAATCATGAAGCCTGG 3925
Chimpanzee 3735 AGGTGCTTTTTA----TGTTATTTAATCGCGAAACCTGG 3769
Rat 2537 AGTGAACTTTTA----CCATATT----GGAG-------- 2559
Mouse 2611 AGTGAACTTTTA----CCATATT----GGAG-------- 2633
Zebrafish 2230 ---AAATTCTCCACTTACATACT----TTC--------- 2252
Fruitfly 697 --------------------------------------- 696
Worm 611 ----------CA----CCA-------------------- 615
Yeast 181 --------------------------------------- 180
Arabidopsis 1117 --GGAAACATCA------CTGTT----GGAG-------- 1135
cons 4486 4524
Human 3926 CCACAGGGTGCTTGTGCATTGA----GTGTGGGAACAAG 3960
Chimpanzee 3770 CCACAGGGCGCTTGTGCATTGA----GTGTGGGAACAAG 3804
Rat 2560 ----------------TAATG----AT-C--TGTGTTTG 2575
Mouse 2634 ----------------TAATG----AT-C--TGAATTTG 2649
Zebrafish 2253 ------------------ATAG----T-G----TAAGCA 2264
Fruitfly 697 --------------------------------------- 696
Worm 616 ------------------ACGGATGC---------ATTT 627
Yeast 181 --------------------------------------- 180
Arabidopsis 1136 ------------------ATGA----T-G-----GTATG 1146
cons 4525 4563
Human 3961 ATTACCATCTCCCTTTTGAGGACACAGGCCTAGAGCAGT 3999
Chimpanzee 3805 ATTACCGTCTCCCTTTTGAGGACACAGGCCTAGAGCAGT 3843
Rat 2576 TTTATAAT----CTTTTAAG------AGCCT-------- 2596
Mouse 2650 CTTACCGT----CATTTAAG------AGCCT-------- 2670
Zebrafish 2265 CTTAATGC----GTTTAAAG------GGCCA-------- 2285
Fruitfly 697 ------GC----C-TATAA-------------------- 704
Worm 628 CT----GC----C-GGT---------------------- 635
Yeast 181 --------------------------------------- 180
Arabidopsis 1147 CCTT---------------------------------CT 1152
cons 4564 4602
Human 4000 TAAGCAGCTTGCTGGAGGTTCACTGGCTAGAAAGTGGTC 4038
Chimpanzee 3844 TAAGCAGCTTGCTGGAGGTTCACTGGCTAGAAAGTGGTC 3882
Rat 2597 CATTCATGTTGCTAGAG---------------------- 2613
Mouse 2671 CATCCATGTTGCGAGAG---------------------- 2687
Zebrafish 2286 CA--AATCACACTTGTG---------------------- 2300
Fruitfly 705 --------------------------------------- 704
Worm 636 --------------------------------------- 635
Yeast 181 --------------------------------------- 180
Arabidopsis 1153 CAA-CATTT------------------------------ 1160
cons 4603 4641
Human 4039 AGCCTGGGATTTGGACACAGATTTTTCCACTCCCAAGTC 4077
Chimpanzee 3883 AGCCTGGGATTTGGACACAGATTTTTCCACTCGCAAGTC 3921
Rat 2614 --CCTT----TTCT-T-C---CTTTCCCTCTT----CTC 2637
Mouse 2688 --CCTT----TTCCTT-T--CCTCTCCTTCTC----CCC 2713
Zebrafish 2301 --CTA----TTTT--T-A---TTTATTT--T--T--TGC 2321
Fruitfly 705 --------------------------------------- 704
Worm 636 --------------------------------------- 635
Yeast 181 --------------------------------------- 180
Arabidopsis 1161 --------GTAT-----CCC--TC--------------- 1169
cons 4642 4680
Human 4078 TGGCTGCTTTTTACTTCACTGTGAGGGGTAAAGGTAAAT 4116
Chimpanzee 3922 TGGCTGCTTTTTACTTCACTGTGAGGGGTAAAGGTAAAT 3960
Rat 2638 C-CCTGCTTT-CCCCTCCCCAC-A----------TAGTG 2663
Mouse 2714 TGCCTTCTT--CCCTTCTCCAC-A----------TAGCC 2739
Zebrafish 2322 T-CTTGATC---ACAG-GCTGC-A----T-----CAGTG 2345
Fruitfly 705 --------------------AT----------------- 706
Worm 636 ------------------CCAC----------------- 639
Yeast 181 --------------------------------------G 181
Arabidopsis 1170 -----------ATCTC--------------AA----G-C 1178
cons 4681 4719
Human 4117 CAGCTGTTTTCTTTGTTCAGAAACTCTCTCCAACTTTG- 4154
Chimpanzee 3961 CAGCTGTTTTCTTTGTTCAGAAACTCTCTGCAACTTTG- 3998
Rat 2664 CA-T-GCT-----AGCCTGGAAT--CTGTG----CTGG- 2688
Mouse 2740 CA--CGGT-----GGCCTGGAAT--TTA-G---TCTTG- 2764
Zebrafish 2346 CA-----------GGTCCGCACT--TCAAC---CC-TCA 2367
Fruitfly 707 ---------------ATTTCCGT--TTA------ACG-- 720
Worm 640 --------------------ACT--TCAAT---CC-AT- 651
Yeast 182 CT-----------GGTCCTCACT--TCAAT---CC-TTT 203
Arabidopsis 1179 ---TT----------------AT--TTA----------- 1185
cons 4720 4758
Human 4155 CACTTTTCT-----TAA--AGGAAAGTAATGGACCAGTG 4186
Chimpanzee 3999 CACTTTTCTTTAATTAA--AGGAAAGTAATGGACCAGTG 4035
Rat 2689 AG-CTTA---------A--A-CCATTTA--GTCT---T- 2708
Mouse 2765 TG-TGTGCT-GTGTTAAAG--GCATGTA----------- 2788
Zebrafish 2368 TGACA----------AA--ACTCATGGT--GGGC---C- 2388
Fruitfly 721 TG-T----------------------------------- 723
Worm 652 TT----GG-------AAAGACTCATGGT----------- 668
Yeast 204 CAAGA----------AG--ACACATGGT--GCTC---C- 224
Arabidopsis 1186 -------------------------GA------------ 1187
cons 4759 4797
Human 4187 AAGGTGTGGGGAAGCATTAAAGGACTGACTGAAGGCCTG 4225
Chimpanzee 4036 AAGGTGTGGGGAAGCATTAAAGGACTGACTGAAGGCCTG 4074
Rat 2709 -AGATGTG---CAGGGTTAAAGGCCA-----TCAACCTG 2738
Mouse 2789 -----------------------CCA-----TCAACCTG 2799
Zebrafish 2389 AACCGA-----TAGTGTGA-GGTGAG-----TTTATCAG 2416
Fruitfly 724 -------G---T-----------CTA-----TTAACAA- 735
Worm 669 --------------------------------------- 668
Yeast 225 A-------------------------------------- 225
Arabidopsis 1188 -------G---CTGTTTT----GC-A-----TCAA---- 1202
cons 4798 4836
Human 4226 CATGGATTCCATGT-TCATGAGTTTGGAGATAATACAGC 4263
Chimpanzee 4075 CATGGATTCCATGT-TCATGAGTTTGGAGATAATACAGC 4112
Rat 2739 TGTG----CAATGT-ACAGTAATTTGGC----CTACAGT 2768
Mouse 2800 TGTG----CTATGT-GCCATAATTTGTT----CTACAGT 2829
Zebrafish 2417 TGTG----CTCTGATAC----ATCTGTT----TTGCAT- 2442
Fruitfly 736 ----------ATGT------TATT--TT----CTATAAT 752
Worm 669 --------------------------------------- 668
Yeast 226 --------------------------------------- 225
Arabidopsis 1203 ---------------------ATTTC-----GCTAC--- 1212
cons 4837 4875
Human 4264 AGGTGGGTGTTGTGCTGTGCTGGTGACCCATACTTGTTC 4302
Chimpanzee 4113 AGGTGGGTGTTGTGCTGTGCTGGTGACCCATACTTGTTC 4151
Rat 2769 TACTTATGTT-----TGTGTT--TGACCCAT-------- 2792
Mouse 2830 TACTTAGGAT-----TGGGTT--TGACCCAT-------- 2853
Zebrafish 2443 GATTTA--------------------CA----------- 2450
Fruitfly 753 AACCTATTA------------------------------ 761
Worm 669 -----------------------GGACC-A--------- 674
Yeast 226 --------------------------------------- 225
Arabidopsis 1213 --------------------------------------- 1212
cons 4876 4914
Human 4303 ACCCTAGTTAGATAAACAGTAGAGTAGCCCCTAAACGTT 4341
Chimpanzee 4152 ACCCTAGTTAGATAAACAGTAGAGTAGCCCCTAAACGTT 4190
Rat 2793 -------TCGGATAATTACTAAAGTTCAA---------- 2814
Mouse 2854 -------TT-GATAATTACTAAAGTTACC---------- 2874
Zebrafish 2451 ----GTATC-TATATATAGTAAAATG----CTAAT-A-- 2477
Fruitfly 762 ------------TCATA--TGAAG--------------- 771
Worm 675 ------------AAAGTATG------------------- 682
Yeast 226 --------------ACTGACGAAGTC----AGAC----- 241
Arabidopsis 1213 --------------------------------------- 1212
cons 4915 4953
Human 4342 AAAACCCCTCAA-CTTGTTTTTGTTTTTGAGAAAGGGTC 4379
Chimpanzee 4191 AAAACCCCTCAA-CTTGTTT------TTGAGAAAGGGTC 4222
Rat 2815 --------TCAA-GTTGCTT------T-G------CCTC 2831
Mouse 2875 --------CCGA-GTTGC------------------CTC 2886
Zebrafish 2478 --------------------------------------- 2477
Fruitfly 772 --------------TTG---------------------- 774
Worm 683 --------------------------------------- 682
Yeast 242 --------------------------------------- 241
Arabidopsis 1213 ----TCTCTCAAATTTGATT------TTGC-----AGTC 1236
cons 4954 4992
Human 4380 TTGCTCTGTCGCTCAGGCTGGAGTGCAGTGGCGCTGTGC 4418
Chimpanzee 4223 TTGCTGTGTCGCTCAGGCTGGAGTGCAGTGGCGCTGTGC 4261
Rat 2832 TGGCCTGGTAGCTTTGGTT-----------------TGT 2853
Mouse 2887 TGGCCTGGTAGCTTTGATT-----------------TGT 2908
Zebrafish 2478 --------------------------------------- 2477
Fruitfly 775 --GCCACGC---------T-----------------CGT 785
Worm 683 --------------------------------------- 682
Yeast 242 --------------------------------------- 241
Arabidopsis 1237 TTA----GTTG-------TATAGTACAGT-------TGT 1257
cons 4993 5031
Human 4419 GATCATGGCTGACCTTAGCCTTG-A-CCTCCCAGGCTCC 4455
Chimpanzee 4262 CATCACGGCTCACCTTAGCCTTG-A-CCTCCCAGGCTCC 4298
Rat 2854 ---TAA-GTT--CCTT--CC-AGAATCC----TG-C-CC 2877
Mouse 2909 ---TAA-GCT--CCTT--CC-AGAATCC----T-GC-CC 2932
Zebrafish 2478 --------------------------------------- 2477
Fruitfly 786 ---T----------------------------------- 786
Worm 683 --------------------------------------- 682
Yeast 242 --------------------------------------- 241
Arabidopsis 1258 ----------CACCTT-----TG-A-CC----A-GCGGT 1274
cons 5032 5070
Human 4456 ATTGATCCTCATGCCTTGGCCCGTAGCTGGGACTACAGG 4494
Chimpanzee 4299 AGTGATCCTCATGCCTTGGCCCGTAGCTGGGACTACAGG 4337
Rat 2878 TGT--ACCTA-TTTCTTGGTCTG--------------G- 2898
Mouse 2933 AGT--TCCTATTTTCTTGGTCTG--------------A- 2954
Zebrafish 2478 --------------------------------------- 2477
Fruitfly 787 --------------------------------------- 786
Worm 683 -------------------------------------G- 683
Yeast 242 --------------------------------------- 241
Arabidopsis 1275 AGTG---TTCATGG-----------------AT-----T 1288
cons 5071 5109
Human 4495 TACACACCACCACGCCTGGCTAATTTTTGTATTTTTTTC 4533
Chimpanzee 4338 TACACACCACCACGCCTGGCTAATTTTTGTATTTTTTTC 4376
Rat 2899 --------------------------------------- 2898
Mouse 2955 --------------------------------------- 2954
Zebrafish 2478 --------------------------------------- 2477
Fruitfly 787 --------------------------------------- 786
Worm 684 --------------------------------------- 683
Yeast 242 --------------------------------------- 241
Arabidopsis 1289 TACATAAAA---------GC----TTTTGTTT------- 1307
cons 5110 5148
Human 4534 TAGAGGTGGGGTTTCATCATGTTGCCCAGGCTGGTCTTG 4572
Chimpanzee 4377 TAGAGGTGGGGTTTCATCATGTTGCCCAGGCTGGTCTTG 4415
Rat 2899 --------------------------------------- 2898
Mouse 2955 --------------------------------------- 2954
Zebrafish 2478 --------------------------------------- 2477
Fruitfly 787 --------------------------------------- 786
Worm 684 --------------------------------------- 683
Yeast 242 --------------------------------------- 241
Arabidopsis 1308 --------TGCTTTT---------CTCAG---------G 1320
cons 5149 5187
Human 4573 AACTGCTGGGCTCAAGTGGTCTATCCTCCTCGACCTCCC 4611
Chimpanzee 4416 AACTGCTGGGCTCAAGTGGTCTATCCTCCTCGACCTCCC 4454
Rat 2899 --------------------------------------- 2898
Mouse 2955 --------------------------------------- 2954
Zebrafish 2478 --------------------------------------- 2477
Fruitfly 787 --------------------------------------- 786
Worm 684 --------------------------------------- 683
Yeast 242 --------------------------------------- 241
Arabidopsis 1321 AACTGC---------------CA-CCTTCACAATCAC-- 1341
cons 5188 5226
Human 4612 AAAGTGCTGGGATTACATGTGTGAGCCACTGTGCCTGGG 4650
Chimpanzee 4455 AAAGTGCTGGGATTACAGGTGTGAGCCACTGTGCCTGGG 4493
Rat 2899 --------------------------------------- 2898
Mouse 2955 --------------------------------------- 2954
Zebrafish 2478 --------------------------------------- 2477
Fruitfly 787 --------------------------------------- 786
Worm 684 --------------------------------------- 683
Yeast 242 --------------------------------------- 241
Arabidopsis 1342 TGATTGCCAGGTTTATAGC-------------------- 1360
cons 5227 5265
Human 4651 AAAACCCTCAACTTTTCTTTTAAAAAAGAGGTCAACTTT 4689
Chimpanzee 4494 AAAACCCTCAACTTTTCTTTTAAAAAAGAGGTCAACTTT 4532
Rat 2899 --------------------------------------- 2898
Mouse 2955 --------------------------------------- 2954
Zebrafish 2478 ------------------------------------TTT 2480
Fruitfly 787 --------------------------------------- 786
Worm 684 --------------------------------------- 683
Yeast 242 --------------------------------------- 241
Arabidopsis 1361 --------------------------------------- 1360
cons 5266 5304
Human 4690 ATTGTATATAAGCACTGTG-CTAAAATTGCAGGAACTGG 4727
Chimpanzee 4533 ATTGTATATAAGCACTGTG-CTAAAGTTGCAGGAACTGG 4570
Rat 2899 --------------------------------------- 2898
Mouse 2955 --------------------------------------- 2954
Zebrafish 2481 ATTGTCTGTACGGATTGTCACTGAAA--GCAGAAACTCT 2517
Fruitfly 787 --------------------------------------- 786
Worm 684 --------------------------------AAAT--- 687
Yeast 242 --------------------------------------- 241
Arabidopsis 1361 ---------------T----------------------- 1361
cons 5305 5343
Human 4728 GACCATATCCTGATTTTTGTAATAAT-GCCAGCAGAGTA 4765
Chimpanzee 4571 GACCATATCTTGATTTTTGTAATAAT-GCCAGCAGAGTA 4608
Rat 2899 --------------------------------------- 2898
Mouse 2955 --------------------------------------- 2954
Zebrafish 2518 -A-CTTGCCCTCAAAGTTG------T-CCCA------TT 2541
Fruitfly 787 --------------------------------------- 786
Worm 688 -----------------TTTTTATATCGCT--------- 700
Yeast 242 --------------------------------------- 241
Arabidopsis 1362 --------------------------------------- 1361
cons 5344 5382
Human 4766 CACACAAGAAAAGTAACTGCACTAGATTGTGAAGACTGG 4804
Chimpanzee 4609 CACACAAGAAAAGTAACTGCACTAGATTGTGAAGACTGG 4647
Rat 2899 ------------------------------GTAGA---- 2903
Mouse 2955 ------------------------------GTAAA---- 2959
Zebrafish 2542 TAC---------TTAAATCC---TGTTTGTTTAAA---- 2564
Fruitfly 787 --------------------------------------- 786
Worm 701 -----------------------TG-----A-------- 703
Yeast 242 --------------------------------------- 241
Arabidopsis 1362 --------------------------------------- 1361
cons 5383 5421
Human 4805 GGTGGACCTGCTTCTGAAGGTCCAGTGCCCTTTGTCTTA 4843
Chimpanzee 4648 GGTGGACTTGCTTCTGAAGGTCCAGTGCCCTTTGTCTTA 4686
Rat 2904 AATTGT--------------------------------- 2909
Mouse 2960 CACTGG--------------------------------- 2965
Zebrafish 2565 AGTTGATCTGCATTTGTCG---CATGGGCCTGTATCTCA 2600
Fruitfly 787 -ATCAT--------------------------------- 791
Worm 704 -ATTAT--------------------------------- 708
Yeast 242 --------------------------------------- 241
Arabidopsis 1362 ----------------------GTGT-ACCT-------- 1369
cons 5422 5460
Human 4844 AGATTTGGTGTAGTGTGTCTTTAGAAACCAAAAAAAGAG 4882
Chimpanzee 4687 AGATTTGGTGTAGTGTATGTTTAGAAACCAAAAAAAGAG 4725
Rat 2910 --------------------------------------- 2909
Mouse 2966 --------------------------------------- 2965
Zebrafish 2601 A--TTTAGGCATGTGTGGTGTCAGAAGAC---------- 2627
Fruitfly 792 --------------------------------------- 791
Worm 709 --------------------------------------- 708
Yeast 242 --------------------------------------- 241
Arabidopsis 1370 --------------------------------------- 1369
cons 5461 5499
Human 4883 AAGAAGATCAACCTTAAGATTAGCCACAAAACTGGGCTT 4921
Chimpanzee 4726 AAG----TCA----------------------------- 4731
Rat 2910 --------------------------------------- 2909
Mouse 2966 --------------------------------------- 2965
Zebrafish 2628 -AGAACATCG----------------------------- 2636
Fruitfly 792 --------------------------------------- 791
Worm 709 --------------------------------------- 708
Yeast 242 --------------------------------------- 241
Arabidopsis 1370 --------------------------------------- 1369
cons 5500 5538
Human 4922 TGATACCTAGGTGTGGAAAAGAAAGGGAAAGAGTTGATG 4960
Chimpanzee 4732 --------------------------------------- 4731
Rat 2910 --------------------------------------- 2909
Mouse 2966 --------------------------------------- 2965
Zebrafish 2637 --------------------------------------- 2636
Fruitfly 792 --------------------------------------- 791
Worm 709 --------------------------------------- 708
Yeast 242 --------------------------------------- 241
Arabidopsis 1370 --------------------------------------- 1369
cons 5539 5577
Human 4961 TTTTGTCTTACAGCATCATTGTAGAAGAGGGTGTTTTTT 4999
Chimpanzee 4732 --------------------------------------- 4731
Rat 2910 --------------------------------------- 2909
Mouse 2966 --------------------------------------- 2965
Zebrafish 2637 --------------------------------------- 2636
Fruitfly 792 --------------------------------------- 791
Worm 709 --------------------------------------- 708
Yeast 242 --------------------------------------- 241
Arabidopsis 1370 --------------------------------------- 1369
cons 5578 5616
Human 5000 TGTTTGTTTGTTTTTTGAGACGGAGTCTTACTCTGTGGC 5038
Chimpanzee 4732 --------------------------------------- 4731
Rat 2910 --------------------------------------- 2909
Mouse 2966 --------------------------------------- 2965
Zebrafish 2637 --------------------------------------- 2636
Fruitfly 792 --------------------------------------- 791
Worm 709 --------------------------------------- 708
Yeast 242 --------------------------------------- 241
Arabidopsis 1370 --------------------------------------- 1369
cons 5617 5655
Human 5039 CCAGGCTGGAGTGCAGTGGCGCGATCTCGGCTCACTGCA 5077
Chimpanzee 4732 --------------------------------------- 4731
Rat 2910 --------------------------------------- 2909
Mouse 2966 --------------------------------------- 2965
Zebrafish 2637 --------------------------------------- 2636
Fruitfly 792 --------------------------------------- 791
Worm 709 --------------------------------------- 708
Yeast 242 --------------------------------------- 241
Arabidopsis 1370 --------------------------------------- 1369
cons 5656 5694
Human 5078 AGCTCCGCCTCCCGGGTTCATGCCATTCTCCTGCCTCAG 5116
Chimpanzee 4732 --------------------------------------- 4731
Rat 2910 --------------------------------------- 2909
Mouse 2966 --------------------------------------- 2965
Zebrafish 2637 --------------------------------------- 2636
Fruitfly 792 --------------------------------------- 791
Worm 709 --------------------------------------- 708
Yeast 242 --------------------------------------- 241
Arabidopsis 1370 --------------------------------------- 1369
cons 5695 5733
Human 5117 CCCCCTGAGTAGCTGGGACTACAGGTGCCCGCCACCCCG 5155
Chimpanzee 4732 --------------------------------------- 4731
Rat 2910 --------------------------------------- 2909
Mouse 2966 --------------------------------------- 2965
Zebrafish 2637 --------------------------------------- 2636
Fruitfly 792 --------------------------------------- 791
Worm 709 --------------------------------------- 708
Yeast 242 --------------------------------------- 241
Arabidopsis 1370 --------------------------------------- 1369
cons 5734 5772
Human 5156 CCTGGCTAATTTTTTGTATTTTTAGTAGAGACGGGGTTT 5194
Chimpanzee 4732 --------------------------------------- 4731
Rat 2910 --------------------------------------- 2909
Mouse 2966 --------------------------------------- 2965
Zebrafish 2637 --------------------------------------- 2636
Fruitfly 792 --------------------------------------- 791
Worm 709 --------------------------------------- 708
Yeast 242 --------------------------------------- 241
Arabidopsis 1370 --------------------------------------- 1369
cons 5773 5811
Human 5195 CACTGTGTTAGCCAAGATGGTCTCTCTCCTGACCTCGTG 5233
Chimpanzee 4732 --------------------------------------- 4731
Rat 2910 --------------------------------------- 2909
Mouse 2966 --------------------------------------- 2965
Zebrafish 2637 --------------------------------------- 2636
Fruitfly 792 --------------------------------------- 791
Worm 709 --------------------------------------- 708
Yeast 242 --------------------------------------- 241
Arabidopsis 1370 --------------------------------------- 1369
cons 5812 5850
Human 5234 ATCCGCCTGTCTCAGCCTCCCAAAGTGCTGGGATTACAG 5272
Chimpanzee 4732 --------------------------------------- 4731
Rat 2910 --------------------------------------- 2909
Mouse 2966 --------------------------------------- 2965
Zebrafish 2637 --------------------------------------- 2636
Fruitfly 792 --------------------------------------- 791
Worm 709 --------------------------------------- 708
Yeast 242 --------------------------------------- 241
Arabidopsis 1370 --------------------------------------- 1369
cons 5851 5889
Human 5273 GCATGAGCCACCGCACCCAGCCAGAAGAGGGTGTTTTTT 5311
Chimpanzee 4732 --------------------------------------- 4731
Rat 2910 --------------------------------------- 2909
Mouse 2966 --------------------------------------- 2965
Zebrafish 2637 --------------------------------------- 2636
Fruitfly 792 --------------------------------------- 791
Worm 709 --------------------------------------- 708
Yeast 242 --------------------------------------- 241
Arabidopsis 1370 --------------------------------------- 1369
cons 5890 5928
Human 5312 AAAGAAGGCAAATAGGAAATAAAAACTTGGGCTCTTAAC 5350
Chimpanzee 4732 --------------------------------------- 4731
Rat 2910 --------------------------------------- 2909
Mouse 2966 --------------------------------------- 2965
Zebrafish 2637 --------------------------------------- 2636
Fruitfly 792 --------------------------------------- 791
Worm 709 --------------------------------------- 708
Yeast 242 --------------------------------------- 241
Arabidopsis 1370 --------------------------------------- 1369
cons 5929 5967
Human 5351 TTTTGTAATGATCCCAGGTGTTTGAGCTGGGGGTTGAGG 5389
Chimpanzee 4732 --------------------------------------- 4731
Rat 2910 --------------------------------------- 2909
Mouse 2966 --------------------------------------- 2965
Zebrafish 2637 --------------------------------------- 2636
Fruitfly 792 --------------------------------------- 791
Worm 709 --------------------------------------- 708
Yeast 242 --------------------------------------- 241
Arabidopsis 1370 --------------------------------------- 1369
cons 5968 6006
Human 5390 GTGGGTGCCTCGAGCAAAGGGGCTGCATTTATTTGCATA 5428
Chimpanzee 4732 --------------------------------------- 4731
Rat 2910 --------------------------------------- 2909
Mouse 2966 --------------------------------------- 2965
Zebrafish 2637 --------------------------------------- 2636
Fruitfly 792 --------------------------------------- 791
Worm 709 --------------------------------------- 708
Yeast 242 --------------------------------------- 241
Arabidopsis 1370 --------------------------------------- 1369
cons 6007 6045
Human 5429 ATGCCATGTAAGAGTAGCTCTACACCCCAAACACAGGCT 5467
Chimpanzee 4732 --------------------------------------- 4731
Rat 2910 --------------------------------------- 2909
Mouse 2966 --------------------------------------- 2965
Zebrafish 2637 --------------------------------------- 2636
Fruitfly 792 --------------------------------------- 791
Worm 709 --------------------------------------- 708
Yeast 242 --------------------------------------- 241
Arabidopsis 1370 --------------------------------------- 1369
cons 6046 6084
Human 5468 TCTTAGTGGGACCAAAGTATGATACAAACTGAAGATGGA 5506
Chimpanzee 4732 --------------------------------------- 4731
Rat 2910 --------------------------------------- 2909
Mouse 2966 --------------------------------------- 2965
Zebrafish 2637 --------------------------------------- 2636
Fruitfly 792 --------------------------------------- 791
Worm 709 --------------------------------------- 708
Yeast 242 --------------------------------------- 241
Arabidopsis 1370 --------------------------------------- 1369
cons 6085 6123
Human 5507 ATGCAGAGGATTATTGGTACTTTGGAATATGCTTAAAAA 5545
Chimpanzee 4732 --------------------------------------- 4731
Rat 2910 --------------------------------------- 2909
Mouse 2966 --------------------------------------- 2965
Zebrafish 2637 --------------------------------------- 2636
Fruitfly 792 --------------------------------------- 791
Worm 709 --------------------------------------- 708
Yeast 242 --------------------------------------- 241
Arabidopsis 1370 --------------------------------------- 1369
cons 6124 6162
Human 5546 AAATTTTTTTAAAGTATTTTTAAAAAATCAGGCAACCCC 5584
Chimpanzee 4732 --------------------------------------- 4731
Rat 2910 --------------------------------------- 2909
Mouse 2966 --------------------------------------- 2965
Zebrafish 2637 --------------------------------------- 2636
Fruitfly 792 --------------------------------------- 791
Worm 709 --------------------------------------- 708
Yeast 242 --------------------------------------- 241
Arabidopsis 1370 --------------------------------------- 1369
cons 6163 6201
Human 5585 TGAACCAGAGTAGGTTCAGAGAAACTGCCAAATTTTATT 5623
Chimpanzee 4732 --------------------------------------- 4731
Rat 2910 --------------------------------------- 2909
Mouse 2966 --------------------------------------- 2965
Zebrafish 2637 --------------------------------------- 2636
Fruitfly 792 --------------------------------------- 791
Worm 709 --------------------------------------- 708
Yeast 242 --------------------------------------- 241
Arabidopsis 1370 --------------------------------------- 1369
cons 6202 6240
Human 5624 TTCTTAATTTGGGATTGGAAGCAAGTTAACAGAAGTTTA 5662
Chimpanzee 4732 --------------------------------------- 4731
Rat 2910 --------------------------------------- 2909
Mouse 2966 --------------------------------------- 2965
Zebrafish 2637 --------------------------------------- 2636
Fruitfly 792 --------------------------------------- 791
Worm 709 --------------------------------------- 708
Yeast 242 --------------------------------------- 241
Arabidopsis 1370 --------------------------------------- 1369
cons 6241 6279
Human 5663 TGAGTTAAGTTGCATTTAGTGATCTTTTGCCATATTTGA 5701
Chimpanzee 4732 --------------------------------------- 4731
Rat 2910 --------------------------------------- 2909
Mouse 2966 --------------------------------------- 2965
Zebrafish 2637 --------------------------------------- 2636
Fruitfly 792 --------------------------------------- 791
Worm 709 --------------------------------------- 708
Yeast 242 --------------------------------------- 241
Arabidopsis 1370 --------------------------------------- 1369
cons 6280 6318
Human 5702 GTAATAATCTGATTTTTTTGTTTATAGATTTCTTCTTAA 5740
Chimpanzee 4732 --------------------------------------- 4731
Rat 2910 --------------------------------------- 2909
Mouse 2966 --------------------------------------- 2965
Zebrafish 2637 --------------------------------------- 2636
Fruitfly 792 --------------------------------------- 791
Worm 709 --------------------------------------- 708
Yeast 242 --------------------------------------- 241
Arabidopsis 1370 --------------------------------------- 1369
cons 6319 6357
Human 5741 ATTAACTTTATTCATCTTGCTAATTTAGTTTCAAATAGT 5779
Chimpanzee 4732 --------------------------------------- 4731
Rat 2910 --------------------------------------- 2909
Mouse 2966 --------------------------------------- 2965
Zebrafish 2637 --------------------------------------- 2636
Fruitfly 792 --------------------------------------- 791
Worm 709 --------------------------------------- 708
Yeast 242 --------------------------------------- 241
Arabidopsis 1370 --------------------------------------- 1369
cons 6358 6396
Human 5780 GATTTGTAATGATCAGATTTGATCCATTTCTGTAATTGC 5818
Chimpanzee 4732 --------------------------------------- 4731
Rat 2910 --------------------------------------- 2909
Mouse 2966 --------------------------------------- 2965
Zebrafish 2637 --------------------------------------- 2636
Fruitfly 792 --------------------------------------- 791
Worm 709 --------------------------------------- 708
Yeast 242 --------------------------------------- 241
Arabidopsis 1370 --------------------------------------- 1369
cons 6397 6435
Human 5819 TGAAATTCCCCCGAGTTGCTTTTTGGCTTTACCGCCTCT 5857
Chimpanzee 4732 --------------------------------------- 4731
Rat 2910 --------------------------------------- 2909
Mouse 2966 --------------------------------------- 2965
Zebrafish 2637 --------------------------------------- 2636
Fruitfly 792 --------------------------------------- 791
Worm 709 --------------------------------------- 708
Yeast 242 --------------------------------------- 241
Arabidopsis 1370 --------------------------------------- 1369
cons 6436 6474
Human 5858 GGTCTGGGAGGTGATTGCTCTGCTGCTTCCTGTAACTTG 5896
Chimpanzee 4732 --------------------------------------- 4731
Rat 2910 -------------------AAACT-----ATGTAAGTC- 2923
Mouse 2966 -------------------AAGT-----CCTGC------ 2974
Zebrafish 2637 --------------------------------------- 2636
Fruitfly 792 -------------------AA------------------ 793
Worm 709 -------------------AA-----------T------ 711
Yeast 242 --------------------------------------- 241
Arabidopsis 1370 --------------------------------------- 1369
cons 6475 6513
Human 5897 CCTGCCTTTCTCCCTGTGTGGGACTCCTGCGGGTGAGAG 5935
Chimpanzee 4732 --------------------------------------- 4731
Rat 2924 -----CT-------------------------------- 2925
Mouse 2975 --------------------------------------- 2974
Zebrafish 2637 --------------------------------------- 2636
Fruitfly 794 --------------------------------------- 793
Worm 712 --------------------------------------- 711
Yeast 242 --------------------------------------- 241
Arabidopsis 1370 --------------------------------------- 1369
cons 6514 6552
Human 5936 CGTGGCTGAAGACAGCCGTGTTATGAAAGGGCCTCCTG- 5973
Chimpanzee 4732 --------------------------------------- 4731
Rat 2926 --------------------AT--TTCCTGAGTTGTTGT 2942
Mouse 2975 --------------------ATATAAAAGGACTTGCTG- 2992
Zebrafish 2637 --------------------------------------- 2636
Fruitfly 794 --------------------------------------- 793
Worm 712 --------------------AT----------------- 713
Yeast 242 --------------------------------------- 241
Arabidopsis 1370 --------------------------------------- 1369
cons 6553 6591
Human 5974 TGCTGT-CGAGGTTGTGCTCTGTGAATGTCATCCCCTGG 6011
Chimpanzee 4732 --------------------------------------- 4731
Rat 2943 TGCTGT-TGAGA-TGTCCCTTGTGAATGATGTCCCTTAG 2979
Mouse 2993 CATTGT-TGAGC-TGTGCCTTGTGACTGGCATCCCTTAG 3029
Zebrafish 2637 --------------------------------------- 2636
Fruitfly 794 --------------------------------------- 793
Worm 714 ---TTTTTCA----------------------------- 720
Yeast 242 --------------------------------------- 241
Arabidopsis 1370 --------------------------------------- 1369
cons 6592 6630
Human 6012 TGCACAGCAGCACCTTCTACACAGGATACAGTTGGAATG 6050
Chimpanzee 4732 --------------------------------------- 4731
Rat 2980 CCCACATGTACACC-TCTA------ATGCTGT----T-- 3005
Mouse 3030 CCCACATGAGTAG-------------TGTGGT----A-- 3049
Zebrafish 2637 AATACAGGGTTTCC-GC-A-------GGGTCTTA----- 2661
Fruitfly 794 -T--CAGTG-------CTT------CTG---C----T-- 807
Worm 721 --------------------------------------- 720
Yeast 242 --------------------------------------- 241
Arabidopsis 1370 --------------------------------------- 1369
cons 6631 6669
Human 6051 CCGCCCCCTCGAGTTGTGTAAGGCAGCAGCCTTGGCCCT 6089
Chimpanzee 4732 --------------------------------------- 4731
Rat 3006 -TA-CACCTGGAGTTGAGAAGCACAGCAGCCTTGACACG 3042
Mouse 3050 -CACCTCCTGGAGTTGAG---GACACCAGCCCTGGCCCT 3084
Zebrafish 2662 ---AAGTCTCAAACTTAAAAAT--CGAAA-TTTTAGGCC 2694
Fruitfly 808 ------CACTATTA------------------------- 815
Worm 721 --------------------------------------- 720
Yeast 242 --------------------------ATG-TCGGTGACA 253
Arabidopsis 1370 --------------------------------------- 1369
cons 6670 6708
Human 6090 TGCACATAAGATGCTGTTGAATATTCTGCCTGCACCAAG 6128
Chimpanzee 4732 --------------------------------------- 4731
Rat 3043 TGGGGATAA-------TCTAAAAATCTGTCTGCCCCAAG 3074
Mouse 3085 TGGGAACAAG---CCATCTAACAGTCTGCCTGCCCCAAG 3120
Zebrafish 2695 TTAAAAAAA-------TCTTTAA-TTTG-CTGTTCTAGG 2724
Fruitfly 816 ------------------TA-----------------CA 819
Worm 721 ----------------GTCCGAGATCCGTC------ACG 737
Yeast 254 TGGG----------------------------------- 257
Arabidopsis 1370 --------------------------------------- 1369
cons 6709 6747
Human 6129 TAAAGGGCACAG-AT--AGAACTGCTT---GGCATATGT 6161
Chimpanzee 4732 --------------------------------------- 4731
Rat 3075 TAAAAGCCAGATGGC--TGAGCTGTTTGGTGGTGTAAGG 3111
Mouse 3121 TAAAAGCTAGACAGG--TGAGCTGTTTGGTGGCACATGG 3157
Zebrafish 2725 TCTTAAATATTT-TTGCACCGGTCTTA-TTTTTCCCATG 2761
Fruitfly 820 CAA---CT--------------TGTG------------- 828
Worm 738 T-------------------------------------- 738
Yeast 258 --------------------------------------- 257
Arabidopsis 1370 --------------------------------------- 1369
cons 6748 6786
Human 6162 TG-----------CTGGGGAGATGAGTTTTTT-G---TA 6185
Chimpanzee 4732 --------------------------------------- 4731
Rat 3112 T------------CTTGAAAGATAAGTGTTTTTATCATG 3138
Mouse 3158 T------------CTAGAAAGATAAGTATTTTTATCATG 3184
Zebrafish 2762 TC-----------CATGTAACACTAC--ATCT-A----- 2781
Fruitfly 829 TCTTATCAGTATTC---------GAGTAT---TATC-TG 854
Worm 739 -----------------------AGGC-----------G 743
Yeast 258 --------------------------------------- 257
Arabidopsis 1370 --------------------------------------- 1369
cons 6787 6825
Human 6186 AAGTATACTACGTTCTTAAGAATTTGGATCAT-AACCAT 6223
Chimpanzee 4732 ----------------------------AGTTAAAATAT 4742
Rat 3139 AT------------CTTAAAAGCAAAGATCTTTAAATGT 3165
Mouse 3185 AAGTATGCTCCCTTCTTAAAAGCCAAGGTCTTTAAATGT 3223
Zebrafish 2782 ---------ATGCTCATTTAA---ATTATTTT---TTGT 2805
Fruitfly 855 AAGC----------GTTATAACCCAATCCC--------- 874
Worm 744 ATC----------------TAGGA----------AATGT 756
Yeast 258 --------------------------------------- 257
Arabidopsis 1370 --------------------------------------- 1369
cons 6826 6864
Human 6224 ---GGGATTTTAATAATA-GAAAAACTGTTGAAGATCAG 6258
Chimpanzee 4743 CTTTGAAGATCAACCTTAAGATTAGCCACAAAACTGGGC 4781
Rat 3166 ---GGGACTTTAACTTTA-GAAGTGCCACTAAAGGTCGC 3200
Mouse 3224 ---GGGACTTTAACTTTA-GAAGTGCCATTAAAGATCAC 3258
Zebrafish 2806 ---TGTTGCTTGGTTTTT-GTGGTGTTGTAGTTGTTTAT 2840
Fruitfly 875 --------TT-----------------------CATC-- 880
Worm 757 ---GGA--------------------------AG----C 762
Yeast 258 ----------TAA-------------CGTAAAG------ 267
Arabidopsis 1370 --------------------------------------- 1369
cons 6865 6903
Human 6259 TCTGGT--CCCTTATTTTTA----CAGTGAAGAAGCCAA 6291
Chimpanzee 4782 TTTGAT-ACCT----AGGTGTGGAAAAGAAAGGG-AAAG 4814
Rat 3201 TTCTGT--TCC----AGT-A----G-AGGAAGGAACCAG 3227
Mouse 3259 ATCTGT--TCC----AGTTA----CAAGGAAGGAACAAG 3287
Zebrafish 2841 TTCAATAGTCC----AAA-T----G-TGGTATAAAAT-G 2868
Fruitfly 881 --CCG---TCC----A---C-----------------AG 890
Worm 763 T-------------------------------------- 763
Yeast 268 --------------------------------------- 267
Arabidopsis 1370 --------------------------------------- 1369
cons 6904 6942
Human 6292 AG--CCCAGAG-AAGGGTGT-TAACTTTACAAG------ 6320
Chimpanzee 4815 AG---TT-GAT--GTTTTGTCTTACAGCATCATTGTAGA 4847
Rat 3228 AG---CTAGAC-A-TGCTGT--GACACTACCAT------ 3253
Mouse 3288 AG--C-CAGGC-A-TGCTGT----CCTGACA-C------ 3310
Zebrafish 2869 CGGTATA-AAAACTACAAAT--GAGACCAACAT------ 2898
Fruitfly 891 AG---CA--------GCGG-----TAC------------ 901
Worm 764 --------------------------------------- 763
Yeast 268 --------------------------------------- 267
Arabidopsis 1370 ---------------------------TTTTA------- 1374
cons 6943 6981
Human 6321 ------TGT---C-AGACAGTAGTTAGAACTTGGTGGGG 6349
Chimpanzee 4848 AGAGGGTGTTTTTTTGTC------TG------------- 4867
Rat 3254 -------GCT------------CCTG------------- 3260
Mouse 3311 ------TGC---C-A------------------------ 3315
Zebrafish 2899 -------GCA--A----------CAGCCAATC------- 2911
Fruitfly 902 -------GCC------------CGT-------------- 907
Worm 764 --------------------------------------- 763
Yeast 268 --------------------------------------- 267
Arabidopsis 1375 ------TGCT--T-------------------------- 1379
cons 6982 7020
Human 6350 TTTTTTTTTTTTTTTTTTTGAGATGGAGTCTTGCTCT-- 6386
Chimpanzee 4868 -------------TTTTTTGAGACGGAGTCTTACTCT-- 4891
Rat 3261 --------------------------------GCACTTG 3267
Mouse 3316 ------------------------------TGGCCCT-- 3322
Zebrafish 2912 --------------------------AG----------- 2913
Fruitfly 908 --------------------------------------- 907
Worm 764 -----------------------------------GG-- 765
Yeast 268 --------------------------------------- 267
Arabidopsis 1380 ------------------------------------T-- 1380
cons 7021 7059
Human 6387 -GTTG--CCCAGGC-TGG-------AGTGCAGTGGTGCG 6414
Chimpanzee 4892 -GTGG--CCCAGGC-TGG-------AGTGCAGTGGCGCG 4919
Rat 3268 GAAGG--CTAAGGT-AGG-------AGG----------- 3285
Mouse 3323 -AAG--GCTAAGGT-GG-------GAGG----------- 3339
Zebrafish 2914 ----C--CTACTGTTATT-------GAACT--------- 2930
Fruitfly 908 -----------------G-------AAG----------- 911
Worm 766 -A-GCCGATGGAGT-GGCAAAAATCAA------------ 789
Yeast 268 --------------------------------------- 267
Arabidopsis 1381 -TTTC--CTAA---------------------------- 1388
cons 7060 7098
Human 6415 ATCTCAGCTCACT----GCAACCTCTGCCTCCCAGGTTC 6449
Chimpanzee 4920 ATCTCAGCTCACT----GCAACCCCTGCCTCCCAGGTTC 4954
Rat 3286 GTCATTAACTGCA----GATATCATGGGCT-----GTGG 3315
Mouse 3340 GTCATAGGTCGCA----GATATCCTGAGCT-----GTAG 3369
Zebrafish 2931 --CA---ATAACGAACTGTTATCAC--GCAG--CGAA-- 2958
Fruitfly 912 GTCT-------CC---------GGTGAGGT-----G--- 926
Worm 790 ------GCTCAC-----------C--------------- 796
Yeast 268 --------------------------------------- 267
Arabidopsis 1389 ---T------------------CCAAACCTG--CTGT-- 1402
cons 7099 7137
Human 6450 AAGCGATTCTCCTGCCTCAGCCTACTAAGTAGCTGGGAC 6488
Chimpanzee 4955 AAGCGATTCTCCTGCCTCAGCCTACTAAGTAGCTGGGAC 4993
Rat 3316 TAGTGAGAC-CCTGTCTCAAAT--CTCAAAA-C------ 3344
Mouse 3370 TAGTGAGAC-ACTGTCTCAAAA--CTCAAAAGC------ 3399
Zebrafish 2959 -TGTGAT-GTCATGGC--ATGCGTCAT---G-------- 2982
Fruitfly 927 ---TGCGGC--CT-------------------------- 934
Worm 797 --------------------------------------- 796
Yeast 268 --------------------------------------- 267
Arabidopsis 1403 -AGTGAA-CC---------AATCTCTTA--A-------- 1420
cons 7138 7176
Human 6489 TATAGGTGCGCACCACCACGCCT----AGCTAATTTTTG 6523
Chimpanzee 4994 TATAGGTGCGCACCACCACGCCT----AGCTAATTTTTG 5028
Rat 3345 ---------AAACAAACATGA------------------ 3356
Mouse 3400 ---------AAACAAA-A---------AGAAAAATGTGA 3419
Zebrafish 2983 --------CGCGCG-ACGTGTT-----T----------- 2996
Fruitfly 935 --------------------------------------- 934
Worm 797 -------------GAC-ACGC-TCGTCA----------- 809
Yeast 268 --------------------------------------- 267
Arabidopsis 1421 --------GAT----ACA--------------------- 1426
cons 7177 7215
Human 6524 TATTTTTTCAGTAGAGACA-GGGTTTTGCTATGCTGGCC 6561
Chimpanzee 5029 TATTTTTTCAGTAGAGACA-GGGTTTTGCTATGTTGGCC 5066
Rat 3357 CA---GTCTAGTGAAAAAGCGGG--TA---------GC- 3380
Mouse 3420 CA---GTCTAGGAAAAAAA-G-G--TA---------GC- 3441
Zebrafish 2997 ---TCGGCTGGT-GG-AGC-GCA--CAG-------G--- 3017
Fruitfly 935 -----GGCCAA---------GGG--------------T- 944
Worm 810 -C---GC-------------------T---------TT- 815
Yeast 268 --------------------------------------- 267
Arabidopsis 1427 -----TTTT-GT--------G------------TTGGC- 1438
cons 7216 7254
Human 6562 AGGCTGGTCTCAAACTCCTGACCTCAGATGATCCAGCCA 6600
Chimpanzee 5067 AGGCTGGTCTCAAACTCCTGACCTCAGATGATCCAGCCA 5105
Rat 3381 --------TTGAAAATGC-AAGGCCATATAGTCCAGCTA 3410
Mouse 3442 --------CTGAGAATGT-AAGGCTATACAGTGCAGCTA 3471
Zebrafish 3018 ---A-------TTATTT--GAGACTC---GGGTGAACAG 3041
Fruitfly 945 --------CT----------------------------- 946
Worm 816 --------ACGG---TC---------------------- 821
Yeast 268 --------------------------------------- 267
Arabidopsis 1439 ---TT--------------------------AACAG--- 1445
cons 7255 7293
Human 6601 CCTCAGCTTCCCAAAGTGCT--GGGGTTCCAGGTGTTAG 6637
Chimpanzee 5106 CCTCAGCTTCCCAAAGTGCT--GGGGTTCCAGGTGTTAG 5142
Rat 3411 TTTG----TACCAGGGTGCT--G--CTTCCTG---TTTG 3438
Mouse 3472 CTTA----CACCAGGGCGCT--G--CTGCC--------- 3493
Zebrafish 3042 TTC------------------------------------ 3044
Fruitfly 947 -----------------GCACGG--ATTCCAC---GTG- 962
Worm 822 -----------CAAA------------------------ 825
Yeast 268 --------------------------------------- 267
Arabidopsis 1446 -------------------------ATTCCTCT------ 1453
cons 7294 7332
Human 6638 CCACCATGCCTGGCCATAGACTTGTTTCTGTTCCCTTCT 6676
Chimpanzee 5143 CCACCATGCCTGGCCATAGACTTGTTTCTGTTCCCTTCT 5181
Rat 3439 -TATCACTCCAGCACAT--AC------------------ 3456
Mouse 3494 ----------------------TGTTTTTATC------- 3503
Zebrafish 3045 --------------------------------------- 3044
Fruitfly 963 -CA-----------------C------------------ 965
Worm 826 ----------------------------CACT------- 829
Yeast 268 --------------------------------------- 267
Arabidopsis 1454 --------------------------------------- 1453
cons 7333 7371
Human 6677 CACTGTGGCTGTACCAAGGTGTTGCTTATCCCAGAAGTC 6715
Chimpanzee 5182 CACTGTGGCTGTACCAAGGTGTTGCTTATCCCAGAAGTC 5220
Rat 3457 --------------------------------------- 3456
Mouse 3504 ---------------------------GCCCCAGCAC-- 3513
Zebrafish 3045 --------------------------------------- 3044
Fruitfly 966 --------------------------------------- 965
Worm 830 ---------------------------G----------- 830
Yeast 268 --------------------------------------- 267
Arabidopsis 1454 TACT------GGAC------------------------- 1461
cons 7372 7410
Human 6716 GTGATGCAGGTCAGCACTTTCTC-CATGGGAAGT-TTTA 6752
Chimpanzee 5221 GTGATGCAGGTCAGCACTTTCTC-CATGGGAAGT-TTTA 5257
Rat 3457 ------CAGCTCCATGTTTGCTG-TGTTGGAAGT-TGTA 3487
Mouse 3514 AT--ACCAGGTCAGTGTTTGCTA-TGTTGGAGGTT-GTA 3548
Zebrafish 3045 --------GCACAGCGTTTGATT-TG----AGTTGAATA 3070
Fruitfly 966 ------GAGTTCGG-----------------------TG 975
Worm 831 ----------TC-------------GT----------TG 836
Yeast 268 --------------------------------------- 267
Arabidopsis 1462 -----CAAACTC---------TATTGTTGG-------TA 1479
cons 7411 7449
Human 6753 GCAGTGTTTCTTTTTAGAA---TGT-ATTTGGGAACTTT 6787
Chimpanzee 5258 GCGGTGTTTCTTTTTAGAA---TGT-ATTTGGGAACTTT 5292
Rat 3488 AGAATTCCGATGTC-A--T---TGC-ATACA-GAGGTTT 3518
Mouse 3549 AGAATGCCTGTGTT-G--T---TAC-ATATA-GGGGTTT 3579
Zebrafish 3071 AGAATCCCTTTGTA-GAGATTTTGTCTGAAA-CGAGTAT 3107
Fruitfly 976 ACAACACCAAT---------------------------- 986
Worm 837 GCC-GATCT------------------------------ 844
Yeast 268 --------------------------------------- 267
Arabidopsis 1480 G-------------------------------------- 1480
cons 7450 7488
Human 6788 AATTCATAATTTAGCT--TTTTTTTCTTCTTCTTATAAA 6824
Chimpanzee 5293 AATTCATAATTTAGCT--TTTTTTTCTTCTTCTTGTAAA 5329
Rat 3519 ACTTCATAATCTGACT--GCTGG-----TTTCTGGTAAA 3550
Mouse 3580 ACTTCATAATCTGACT--GCTGG-----TTTCTGGTAAA 3611
Zebrafish 3108 ACGACTTTA-CAGACACCATTA-----TGATCTG-TCCA 3139
Fruitfly 987 ------------GGCT--GCAT----------------- 994
Worm 845 --------AT--GGTT----------------------- 850
Yeast 268 --------------------------------------- 267
Arabidopsis 1481 ------------GGCT--GTTG----------------- 1488
cons 7489 7527
Human 6825 TAGGCTGTACCAGTGCAGGTCCTCACTTTAATCCTCTAT 6863
Chimpanzee 5330 TAGGCTGTACCAGTGCAGGTCCTCACTTTAATCCTCTAT 5368
Rat 3551 TAGGCTGTACCACTGCAGGACCTCATTTTAATCCTCACT 3589
Mouse 3612 TAGGCTGTACCAGTGCAGGACCTCATTTTAATCCTCACT 3650
Zebrafish 3140 T--G-CGTGATAGTGGAGAACCAGATGACAAA--TAATT 3173
Fruitfly 995 ---GTCGT-------CCGGACCGCACTTCAATCCGTATG 1023
Worm 851 ------GTT-C-ATGCCGGACAAGACGACC-TC------ 874
Yeast 268 --------------------------------------- 267
Arabidopsis 1489 ----TTGT-CCA-TGCAGACCCTGATGA----CCT---- 1513
cons 7528 7566
Human 6864 CCAGAAAACACGGTGGGCCAAA-GGATGAAGAGAGGTAA 6901
Chimpanzee 5369 CCAGAAAACACGGTGGGCCAAA-GGATGAAGAGAGGTAA 5406
Rat 3590 CTAAGAAACATGGCGGTCCAGC-GGATGAAGAGAGGTGA 3627
Mouse 3651 CTAAGAAACATGGTGGCCCGGC-GGATGAAGAGAGGTGA 3688
Zebrafish 3174 CTTAGCCAGATTGCAAC--AGCTGTGGGAAAAGATGAAA 3210
Fruitfly 1024 GCAAGG--------------------------------A 1030
Worm 875 -----------------------GGT------------- 877
Yeast 268 --------------------------------------- 267
Arabidopsis 1514 ---------------------C-GGA--AAG---GGTAA 1525
cons 7567 7605
Human 6902 CA-AGA-TGCTTAACTCTTGTAATAATGGCGATAGCTTT 6938
Chimpanzee 5407 CA-AGA-TGCTTAAGTCTTGTAATAATGGCGATAGCTTT 5443
Rat 3628 GCAGCA-TTCTC------TCTATGCATGGTGGTGG---A 3656
Mouse 3689 GCAGCA-CGCTC------TGTATGCATGGTGGAGG---A 3717
Zebrafish 3211 GC-TTTTGTTAA--AGTTTGAAAAAAACATGAGGGATAA 3246
Fruitfly 1031 GC-----------------------ATGGCGC------- 1039
Worm 878 --------------------------------------- 877
Yeast 268 -----------A--CGGA--------------------- 272
Arabidopsis 1526 --------------------------------------- 1525
cons 7606 7644
Human 6939 CTGGAGTTCATATGGTATACTACTT----GTAAATATGT 6973
Chimpanzee 5444 CTGGAGTTCATATGGTATACTACTT----GTAAATATGT 5478
Rat 3657 GAGGGGTC--TGTGGAAAACA-CCT----GAAG------ 3682
Mouse 3718 GAGGGGTC--TGTGGAGGACC-CCA----GTAA------ 3743
Zebrafish 3247 -----------GTTTAAGCCAAAAGTGGTCATGGCA-AA 3273
Fruitfly 1040 TC------------------------------------- 1041
Worm 878 --------------------------------------- 877
Yeast 273 --------------------------------------- 272
Arabidopsis 1526 -----TG-----------ACCTT---------------- 1532
cons 7645 7683
Human 6974 GCT----------------AAGATAATTCCGTGTTTCCC 6996
Chimpanzee 5479 GCT----------------AAGATAATTCCGTGTTTCCC 5501
Rat 3683 --------------------ACAGAACTGAGTGGTCTCA 3701
Mouse 3744 -------------------GACAGAACTGCATGGCCT-C 3762
Zebrafish 3274 AGTGAACCAGGTACACAATTACAGAAT---ATGTTTTTT 3309
Fruitfly 1042 --------------------------------------- 1041
Worm 878 --------------------------------------- 877
Yeast 273 --------------------------------------- 272
Arabidopsis 1533 --T----------------GAC----C----------AT 1539
cons 7684 7722
Human 6997 CCACCTTTGCTTTTGAACTTG--CTGACTCATCTAAA-- 7031
Chimpanzee 5502 CCACCTTTGCTTTTGAACTTG--CTGACTCATCTAAA-- 5536
Rat 3702 CTGCCTTTTCTTTTGTATGTT--TCCATTCACCCAAC-- 3736
Mouse 3763 CTGCCTCTGCTTTTGTGTTTGTTTCCATTCACCCAACTC 3801
Zebrafish 3310 GTAAGTGTACTTTTTTTTGCT--TTTATACAT-TAA--- 3342
Fruitfly 1042 --------------------------------------- 1041
Worm 878 --------------------------------------- 877
Yeast 273 -------------------------CGAAAAT-GGT--- 282
Arabidopsis 1540 TTA--TTTTCTTGAGA----T--TTTATTTACCCATA-- 1568
cons 7723 7761
Human 7032 --CCCCT-GCTCCCAAATGCTGGAATGCTTTTACTTCCT 7067
Chimpanzee 5537 --CCCCT-GCTCCCAAATGCTGGAATGCTTTTACTTCCT 5572
Rat 3737 --TCCCACATCCCCAAGTACTGGAATAGTTTA---TATT 3770
Mouse 3802 ACTCCCACAACCCCACGTGCTAGAATAGCTTC---TGTT 3837
Zebrafish 3343 ----------------TTGGCAGAACTG-----T----T 3356
Fruitfly 1042 --------CCGTCGAC----GAGAATCGT--C---ACCT 1063
Worm 878 --------------------------------------- 877
Yeast 283 ----------------GTGGC-CAAGGG-----C----T 295
Arabidopsis 1569 --TT------------ATG-------------------- 1573
cons 7762 7800
Human 7068 GGGCTTAAAGGAATTGACAAATGGGGACACTTAAAACGA 7106
Chimpanzee 5573 GGGCTTAAAGGAATTGACAAATGGGGACACTTAAAACGA 5611
Rat 3771 GGG--TGAAGGAGCTGACAAATGTGGACTCTTA-AGTGA 3806
Mouse 3838 GGG--TGAAGGAGCTGACAAATGTGGACTCTTAAAGTGA 3874
Zebrafish 3357 CGAG--ACATGAACAAAAGCAAGTGATGCATCAAAG--- 3390
Fruitfly 1064 GGG---------------------------------CGA 1069
Worm 878 --------------------------------------- 877
Yeast 296 CCTT--CAA---------------GGACTCTT------- 310
Arabidopsis 1574 -------------CTAACAGA------ATTTAAAAGTTA 1593
cons 7801 7839
Human 7107 TTTGGTTTTGTAGCATTTATTGAATATAGAACTAATACA 7145
Chimpanzee 5612 TTTGGTTTTGTAGCATTTATTGAATATAGAACTAATACA 5650
Rat 3807 TTTAGTTTTGTAGCATTTATTGAAGAT-GAACTAATACA 3844
Mouse 3875 TTTGGTTTTGTAGCATTTATTGAAGAT-GAACTAATACA 3912
Zebrafish 3391 TTTGATTTTAAAAAAA-TCTTGAA--TG---GTTATAAA 3423
Fruitfly 1070 TCTGG----GCAACAT----TGAG--------------- 1085
Worm 878 -------------------------AT-GAAC------- 883
Yeast 311 --TG----------------------------------- 312
Arabidopsis 1594 GCCAGTC------CGT---TTGAG--------------- 1608
cons 7840 7878
Human 7146 AGTGCCAAAGGGGAACTA----------ATACAGGAAAT 7174
Chimpanzee 5651 AGTGCCAAAGGGGAACTA----------ATACAGGAAAT 5679
Rat 3845 AGTGCCAAAA-GGAACCA----------ATACAGAAAAT 3872
Mouse 3913 AGTGCCAAAA-GGAACCA----------ATACAGAAAAT 3940
Zebrafish 3424 AATCTTTA---T-AATCA----------TTTTAATAA-- 3446
Fruitfly 1086 ---GCCACCG-GCG------------------------- 1095
Worm 884 -----------------AATTCGAATTAA---------- 895
Yeast 313 --------------------------------------- 312
Arabidopsis 1609 ----------GGCATCCA----------ATGTAGAATGC 1627
cons 7879 7917
Human 7175 GTCATG---AACAGTACTGTCAACCACTAGCAAAATCAA 7210
Chimpanzee 5680 GTCATG---AACAGTACTGTCAACCACTAGCAAAATCAA 5715
Rat 3873 ATCATGGATAACAGTACTATCAGTCACTAGCAAAGTAAA 3911
Mouse 3941 ATCATGGATAACAGTACTGTCAGTCACTGGCAAAGTAAA 3979
Zebrafish 3447 ATCATAAAAAATAAGTTTAAAAATCTT--G--AACGAT- 3480
Fruitfly 1096 ---------------ACTGCC--CCA---CCAAGGTCAA 1114
Worm 896 --------------------------------AAATCAA 902
Yeast 313 ATC------------------------------------ 315
Arabidopsis 1628 -TTATG---A------------TTCA------ACATC-- 1642
cons 7918 7956
Human 7211 TCATCATTGTGAAACATAGGAAGCTTCTGTAGATAAAAA 7249
Chimpanzee 5716 TCATCATTGTGAAACATAGGAAGCTTCTGTAGATTAAAA 5754
Rat 3912 TC---ATTGTATAATAT-----ACTAATGCAGAT----- 3937
Mouse 3980 TC---ATTGTATAA--TAGGACGCTAATGCAGAT----- 4008
Zebrafish 3481 --ATTA----ATGA--TATGACG------TA-------- 3497
Fruitfly 1115 -C---ATCA------------------------------ 1119
Worm 903 T------------T--TAG-------------------- 907
Yeast 316 --------------------------------------- 315
Arabidopsis 1643 -CATC---CT--AA-----GA-------ACA-------- 1655
cons 7957 7995
Human 7250 AAAAAATTGATACTGAAAACTAGTCGAGACTCCATTTAT 7288
Chimpanzee 5755 -AAAAATTGATACTGAAAACTAGTCGAGACTCCATTTAT 5792
Rat 3938 -----------AATAAAAACTAGTTGAGATTCCGTTTGT 3965
Mouse 4009 -----------AATGAAAACTAGTTGAGATTCCATTTGT 4036
Zebrafish 3498 --------GTTCCTGAA-ACTTCCTATTTCTCTGTTTAT 3527
Fruitfly 1120 ------------CC-------------GACTCCA----- 1128
Worm 908 ---------------TAAACT--------TTCC------ 917
Yeast 316 --------------------------------------- 315
Arabidopsis 1656 --------GTTTAT--AACCTAGTG------TCATTGGT 1678
cons 7996 8034
Human 7289 ATGTGTATGTTTTCTGAAAGCCTTTCAGAAAAATATTAA 7327
Chimpanzee 5793 ATGTGTATGTTTTCTGAAAGCCTTTCAGAAAAATATT-- 5829
Rat 3966 ATGTGAAA-CCTTAGGAAAGTCCTACATTTAAA------ 3997
Mouse 4037 ATGTGAAA-CCTTAGGAAAGTCCTAAAT--AAA------ 4066
Zebrafish 3528 GCGTCTG-ACTTTACGGTGGCTTT--CTTTTCA------ 3557
Fruitfly 1129 --------------------------------------- 1128
Worm 918 --------------------------AG--G-------- 920
Yeast 316 -----AA-GCTTATCG--GT------------------- 327
Arabidopsis 1679 GTTT-------------------TACATTTCAG------ 1692
cons 8035 8073
Human 7328 ATTTAAGGACAA---GATTTTTATATCAGAGGCC-TTGG 7362
Chimpanzee 5830 ---AAAGGACAA---GATTTTTATATCAGAGGCC-TTGG 5861
Rat 3998 ---GAGGGGCTAGCTTGCTTTTGGAATGGAGGCC-TGGG 4032
Mouse 4067 ---GAAGGGCTAGCCTGTTTTTAGAATGGGGGCC-TGGG 4101
Zebrafish 3558 ---TT-GCCCCTGTCGTTTTAAAGAGCCTCGTCCATTTG 3592
Fruitfly 1129 --------------------------------------- 1128
Worm 921 --------------------------------CG-AGGG 926
Yeast 328 -----------------------------CCTA------ 331
Arabidopsis 1693 ----------------------------GAGGCC-ATG- 1701
cons 8074 8112
Human 7363 GA-------CATAGCTTTGTTAGC---T-AT--GCC--A 7386
Chimpanzee 5862 GA-------CATAGCTTTGTTAGC---T-AT--GCC--A 5885
Rat 4033 AG-------CAAACCTTTGCTAAT---C-AGGAGCTG-- 4058
Mouse 4102 AG-------CAAACCTTTGCTAAC---TCAGGAGCTG-- 4128
Zebrafish 3593 AG-------GTGC-CCTCGCAGTCAGCG-AA--GGTGCG 3620
Fruitfly 1129 --------------------------------------- 1128
Worm 927 AGTCGGAGACA---------------------------- 937
Yeast 332 --------------------------------------- 331
Arabidopsis 1702 --------------------------------------- 1701
cons 8113 8151
Human 7387 G--TAATTAAC---AG--------GCATAACTCAGTA-- 7410
Chimpanzee 5886 G--TAATTAAC---AG--------GCATAACTCAGTA-- 5909
Rat 4059 ACATCCTTT---------------TCGAAAGTCCTAG-- 4080
Mouse 4129 GCATACTTTACTAAAG--------CCCCAGATTATGACT 4159
Zebrafish 3621 TGATGCAGCACC-AGG--------CGACAGCATAAGATG 3650
Fruitfly 1129 -----------------------------------AG-- 1130
Worm 938 --AG-----------GCAGAAGAGTCCAAGAAGA----- 958
Yeast 332 --------------------------------------- 331
Arabidopsis 1702 ----------------------------AACTCAG---- 1708
cons 8152 8190
Human 7411 --ACTGAGAGTTTACCCTTTGGTACTTCTGAAATCAGGT 7447
Chimpanzee 5910 --ATTGAGAGTTTACCCTTTGGTACTTCTGAAATCAGGT 5946
Rat 4081 --ACTGTGGCTCTCTCCTTTA-AACTGGAAGAGCTATGT 4116
Mouse 4160 CTTCTCAGAGCACTACCTTTA-AACTTGAAGAACTGTCT 4197
Zebrafish 3651 TTTGTTTGTTTTTTTTTCCTATAGTTCAATGATGCATCT 3689
Fruitfly 1131 --ATTACG-CTCTTC------------------------ 1142
Worm 959 ------------------------CTGGAAACGC----- 968
Yeast 332 --------------------------------------- 331
Arabidopsis 1709 --CCTG--GC------------TACTGGAAACG-CAG-- 1728
cons 8191 8229
Human 7448 GC--AG-CCCCAT-----CTTTCTTCCCAGAGC---ATT 7475
Chimpanzee 5947 GC--AG-CCCCAT-----GTTTCTTCCCAGAGC---ATT 5974
Rat 4117 GT--CA-AGGTATCCTGGCTACCTGTTTTGAA------- 4145
Mouse 4198 GTCAAGGTATCCTGT-AGCTACCTGTTTTGAAC---TTT 4232
Zebrafish 3690 AACCTG-TCTTCAGT-A-CTGTTCAATTTGAATACATTT 3725
Fruitfly 1143 --------------------------------------- 1142
Worm 969 ----CGGA--------GCT----CGTGCTG--------- 982
Yeast 332 --------------------------------------- 331
Arabidopsis 1729 GC--G----------------GCCGTGTTG-------CT 1742
cons 8230 8268
Human 7476 -AGTGTGTAGACGTGAAGCCTTGTT-TGA-AGAG----- 7506
Chimpanzee 5975 -AGTATGTAGACGTGAAGCCTTGTT-TGA-AGAG----- 6005
Rat 4146 --ATTTGTGTTTCCAGACCTTTGTCTGGA-AAAG----- 4176
Mouse 4233 GTGTTTCCAGACCTT-TGCCG-GTCTGGA-AAAG----- 4263
Zebrafish 3726 GTTTTACCACAAATTTTGCGTTTTC-TCTTTATGCGTAT 3763
Fruitfly 1143 ------------------------------GGCG----- 1146
Worm 983 ------C-------------------------------- 983
Yeast 332 --------------------------------------- 331
Arabidopsis 1743 -TGC---------------G--GTA-AGT-AAAA----- 1756
cons 8269 8307
Human 7507 CT------GT---AT--T-TAGAATGCCTAGCTA-CTTG 7532
Chimpanzee 6006 CT------GT---AT--T-TAGAATGCCTAGCTA-CTTG 6031
Rat 4177 CC------ATCATAT--TTGATAGTGTATGTGCA-CTCT 4206
Mouse 4264 CC------ATCATAG--TTGATAATGTATGTGTA-CTTT 4293
Zebrafish 3764 GC------AT---GTTTTTGGTATTGTG-ATATAGGTCT 3792
Fruitfly 1147 CCGACAGCAT----------------------------- 1156
Worm 984 --------------------------------------- 983
Yeast 332 --------------------------------------- 331
Arabidopsis 1757 -C------AA---AA--T------------T--A-CATT 1768
cons 8308 8346
Human 7533 TTTGCAAATTTGT----G----TCT-ACTCAGTCAAGTT 7562
Chimpanzee 6032 TTTGCAAATTTGT----G----TCT-ACTCAGTCAAGTT 6061
Rat 4207 TTAATCCACTCAT----A-G---CA-TTTGACTTCGATG 4236
Mouse 4294 TTCATCCACTCATACGTA----TTTGACTTAGTCAGATT 4328
Zebrafish 3793 TAAATG---TAAT----ACTTAATGGCCTTAA--AGTCT 3822
Fruitfly 1157 --------------------------------------- 1156
Worm 984 --------------------------------------- 983
Yeast 332 --------------------------------------- 331
Arabidopsis 1769 TTT-----CTCAC-----------A-TC----------- 1779
cons 8347 8385
Human 7563 TT--AA-TTTAGCTCATGAACTACCT-TGATGTTTAGTG 7597
Chimpanzee 6062 TT--AA-TTTAGCTCATGAACTACCT-TGATGTTTAGTG 6096
Rat 4237 TG--AA-TTTAGCTATTGAACTCTAT-TGATGTGAAATA 4271
Mouse 4329 TT--AA-CTTAGTTATTGAACTCTAGT-GATGTGAAATA 4363
Zebrafish 3823 TTAAAAGTCTTG-AATTTGACACTATGATATCTGCAA-- 3858
Fruitfly 1157 --------------------------------------- 1156
Worm 984 --------------------------------------- 983
Yeast 332 --------------------------------------- 331
Arabidopsis 1780 ---------------------TC------CTGTGAAA-- 1789
cons 8386 8424
Human 7598 -GCATCA------------GCCCTAA---TCCAT-CTGA 7619
Chimpanzee 6097 -GCATCA------------GCCCTAA---TCCAT-CTGA 6118
Rat 4272 GATATCA------------TTGCTTA---TCCAC-CTGG 4294
Mouse 4364 GACATCA------------TTGTTCA---TCCAC-CTGA 4386
Zebrafish 3859 -AAATCC-------------TGCAAT---AGCAT-TTTA 3879
Fruitfly 1157 -----CATCGGACGCACCGTT----GTCGTGCACGCCGA 1186
Worm 984 --------------------------------C------ 984
Yeast 332 --------------------------------------- 331
Arabidopsis 1790 ---ACCA-------------TGTATA---TT-------- 1801
cons 8425 8463
Human 7620 TG-----CTTTTTCATT--------------ATTAGGCA 7639
Chimpanzee 6119 TG-----CTTTTTCATT--------------ATTAGGCA 6138
Rat 4295 TG-----CTGTTTTAAT--------------GTTAGGCA 4314
Mouse 4387 TG-----CTGTTTTAAT--------------GTTAGGCA 4406
Zebrafish 3880 TGATTTTCTTTTTTATT--------------TTTTGTCA 3904
Fruitfly 1187 TG------------------------------------- 1188
Worm 985 --------------------------------------- 984
Yeast 332 --CCTCCGTTGTAGGCAGAAGCGTCGTTATCC------A 362
Arabidopsis 1802 -------CTA-TTTAAT--------------CTTGATCA 1818
cons 8464 8502
Human 7640 T---------------GTTGGAGACTTGGGCAATGTGAC 7663
Chimpanzee 6139 T---------------GTTGGAGACTTGGGCAATGTGAC 6162
Rat 4315 T---------------GTTGGAGACCTGGGCAATGTGGC 4338
Mouse 4407 T---------------GTTGGAGACCTGGGCAATGTGAC 4430
Zebrafish 3905 A---------------AA---------GAGGAACTTAAA 3919
Fruitfly 1189 --------------------------------------- 1188
Worm 985 --------------------------------------- 984
Yeast 363 --------------------------------------- 362
Arabidopsis 1819 TTACCATCATTGTCACCTT--AGA--------------- 1840
cons 8503 8541
Human 7664 TGC-TGACAAAGATGGTGT---------G----GCCGAT 7688
Chimpanzee 6163 TGC-TGACAAAGATGGTGT---------G----GCCGAT 6187
Rat 4339 TGC-TGGAAAGGACGGTGT-------------GGCCAAT 4363
Mouse 4431 TGC-TGGAAAGGACGGTGT-------------GGCCAAT 4455
Zebrafish 3920 AAAAAAAAAAACATGGC-T---------A----CCCAAT 3944
Fruitfly 1189 ----------------------------------CCGA- 1192
Worm 985 TG-----------CGGTGTCATTGCTCTCGCTGCTC--- 1009
Yeast 363 --------------------------------------- 362
Arabidopsis 1841 --------------------------------------- 1840
cons 8542 8580
Human 7689 GTGTCTATTGAAGATTCTGTGATCTCACTCTCAGGAGAC 7727
Chimpanzee 6188 GTGTCTATTGAAGATTCTGTGATCTCACTCTCAGGAGAC 6226
Rat 4364 GTGTCCATTGAAGATCGTGTGATCTCACTCTCAGGAGAG 4402
Mouse 4456 GTGTCCATTGAAGATCGTGTGATCTCACTCTCAGGAGAG 4494
Zebrafish 3945 -TGAAAAATGAAAATGAAA--ATTTTTAAATGAAGTGTA 3980
Fruitfly 1193 -------------------TGATCT-------------- 1198
Worm 1010 --------------------------------------- 1009
Yeast 363 --------------------------------------- 362
Arabidopsis 1841 --CTCCATTGA---TTCTCTGGT--AACT--CGGG-G-- 1867
cons 8581 8619
Human 7728 CATTGCATCATTGGCCGCACACTGGTGGTAAGTT-TTCA 7765
Chimpanzee 6227 CATTGCATCATTGGCCGCACACTGGTGGTAAGTT-TTCA 6264
Rat 4403 CATTCCATCATTGGCCGTACTATGGTGGTAAGTT-TCCA 4440
Mouse 4495 CATTCCATCATTGGCCGTACAATGGTGGTAAGTTTTTCA 4533
Zebrafish 3981 AA---TAGCATTACACATATTAA-TTGGCAA-TA-AACA 4013
Fruitfly 1199 -----------TGGCC-----AGGGTGG----------- 1210
Worm 1010 --------------------------------------- 1009
Yeast 363 --------------------------------------- 362
Arabidopsis 1868 ---TTCATCT----------------------------- 1874
cons 8620 8658
Human 7766 TAAAAGGAT--ATGC--ATAAAACTTCTTCTAACATACA 7800
Chimpanzee 6265 TAAAAGGAT--ATGC--ATAAAACTTCTTCTAACATACA 6299
Rat 4441 TATAGTAGT--AGAT--GTAGGATTTCTTCTAACAT--A 4473
Mouse 4534 TATAAGGATATATAC--ATAGGATTTCTTCTAACAT--A 4568
Zebrafish 4014 AAAAGCTAT--AAATAAATAGAATATA-AATAATAC--C 4047
Fruitfly 1211 --------------------------------------- 1210
Worm 1010 --------------------------------------- 1009
Yeast 363 --------------------------------------- 362
Arabidopsis 1875 --------------------------------------- 1874
cons 8659 8697
Human 7801 GTCATGTATCTTTTCA---CTT-----TGATTGTTAGTC 7831
Chimpanzee 6300 GTCATGTATCTTTTCA---CTT-----TGATTGTTAGTC 6330
Rat 4474 GTTATGTACCTTTCCATGACTTCGTGGTGGTGGTTAAAC 4512
Mouse 4569 GTTATGTACCTTCCCATGACTTTA---TGGTGGTTAAAC 4604
Zebrafish 4048 GTCCCGTGGGCAGCGA---GAA-----TCGCCAACAAAG 4078
Fruitfly 1211 ----------ACA-------------------------- 1213
Worm 1010 ------------CCC------------------------ 1012
Yeast 363 --------------------------------------- 362
Arabidopsis 1875 ------------------------------TGGTTTATC 1883
cons 8698 8736
Human 7832 G-----CGGTTTCTAAAGATCCAGATAAACTGTACTTGC 7865
Chimpanzee 6331 G-----CGGTTTCTAAAGATCCAGATAAACTGTACTTGC 6364
Rat 4513 ------TAGTTCCTAAAAGATCACATAAATTGG--TAAG 4543
Mouse 4605 ------TAGTTTCTAAAGAGTCACATAAATTGT--TAAG 4635
Zebrafish 4079 AAGTCCTAGTGTGCATCAAGCCAAAGACCTCG---CCGG 4114
Fruitfly 1214 --------------------------------------- 1213
Worm 1013 --------------------------------------- 1012
Yeast 363 ------------------------------CG---CCG- 367
Arabidopsis 1884 T-----A----------------------TT-------- 1887
cons 8737 8775
Human 7866 AGTTCAAATT-AGGAAA-A---GCAATTTTATTGGACAA 7899
Chimpanzee 6365 AGTTCAAATT-AGGAAA-A---GCAATTTTATTGGACAA 6398
Rat 4544 AGTTCAGAAT-AGGAAA-AAATATTATTTTATTGGAT-G 4579
Mouse 4636 AGTTCAGGGT-AGGAAA-A-AAGTTCTTTTATTGGCT-G 4670
Zebrafish 4115 AGGCCAAGATCACCAAACAGAAATTATCCTATTCTAT-C 4152
Fruitfly 1214 --------------------------------------- 1213
Worm 1013 --------------------------------------- 1012
Yeast 368 --GCCAAGATGA--------------------------- 377
Arabidopsis 1888 ------GAC---------T---ATTATTATCTTGCAT-- 1906
cons 8776 8814
Human 7900 TTACGGTGAAAATGAATTATTTTATCTAGGTCAGTTAAG 7938
Chimpanzee 6399 TTACGGTGCAAATGAATTATTTTATCTAGGTCAGTTAAG 6437
Rat 4580 TAATAGT---AAAGAATTAATTTGCCTAGGTCAGTTAAG 4615
Mouse 4671 TGATAGT---AAAGAATTAATTTGCCTAGGTCAGTTAAG 4706
Zebrafish 4153 CT----TCCCCATGTCATGCGTAG--CAATTCACTCAAG 4185
Fruitfly 1214 --------------------------------------- 1213
Worm 1013 --------------------------------------- 1012
Yeast 378 --------------------------------------- 377
Arabidopsis 1907 --------------------TTTG--GGGGTC------- 1916
cons 8815 8853
Human 7939 AACACTGTTCTGCTAA-GATG--CAGTAAAAAGCAGGTT 7974
Chimpanzee 6438 AACACTGTTCTGCTAA-GATG--CAGTAAAAAGCAGGTT 6473
Rat 4616 AACGCTGTTCTGCTGA-AGTG--CGGTAGAAAGCTGGTT 4651
Mouse 4707 AACACTGTTGTGCTGA-AATG--CAGTAGAAAGCAG-TT 4741
Zebrafish 4186 AAGGCAGTCTTGCTGGGAATGGTCAGT-GAAAGTAG-GA 4222
Fruitfly 1214 --------------------------------------- 1213
Worm 1013 --------------------------------------- 1012
Yeast 378 -------CT------------------------------ 379
Arabidopsis 1917 ---------CAACTGA-A-TG----GTAAAA-------- 1932
cons 8854 8892
Human 7975 ACATTTGACCATATTAGATCTG-AGTTTGGAAAACAGAA 8012
Chimpanzee 6474 ACATTTGACCATATTAGATCTG-AGTTTGGAAAACAGAA 6511
Rat 4652 ACATTTGATCAGACTGGATCTG-AGTTGAGGATACA--- 4686
Mouse 4742 ACATTTGATGAGACTGGATCTG-AGTTGAGGATACA--- 4776
Zebrafish 4223 G------GAAAGGCTGCCCAAGAACTTG----------- 4244
Fruitfly 1214 ---------CGAG------CTG-A-GCA----------- 1224
Worm 1013 --------------------------------------- 1012
Yeast 380 --------------------------------------- 379
Arabidopsis 1933 ---TT--ATCAAACTG-A-------TTGA---------- 1948
cons 8893 8931
Human 8013 GTAGTCTTTAGTT---TTAAAATG-------GCCAGATT 8041
Chimpanzee 6512 GTAGTCTTTAGTT---TTAAAATG-------GCCAGATT 6540
Rat 4687 ATAGTCTTTAGT----TTAAAACA-------GCTGGATT 4714
Mouse 4777 ATAGTCTTTAGT----CTAAAACA-------GCCGGATT 4804
Zebrafish 4245 -------TTGGC----TCGATACT-------GTCAAATC 4265
Fruitfly 1225 ---------AGT----CAA-------------------- 1230
Worm 1013 --------------------------------------- 1012
Yeast 380 -------TAGGTAAGGGTGACACTGAAGAATCT------ 405
Arabidopsis 1949 ----CCTTTTGT----CTATGAC---------------T 1964
cons 8932 8970
Human 8042 TTCTTGC--CAGGATTGGGTTTCTCACTTGTTAAACAGA 8078
Chimpanzee 6541 TTCTTGC--CAGGATTGGGTTTCTCACTTGTTAAACAGA 6577
Rat 4715 TTCTTGC--CATGATTGC-CCCCTTACA-GTTA-----A 4744
Mouse 4805 TTCTTGC--CATGATTGC-CCCCCCCCTTGC-------A 4833
Zebrafish 4266 TTATACCAACATGAGCA-TGCGCT--AAC-TCAA----- 4295
Fruitfly 1231 --------------------------CG-GGC------A 1236
Worm 1013 --------------------------------------- 1012
Yeast 406 --------------------------------------- 405
Arabidopsis 1965 TCGCAGG--C-----------------------A----- 1973
cons 8971 9009
Human 8079 ACATTTTGTTAAGTTTAAAACCTGGG------------- 8104
Chimpanzee 6578 ACATTTTGTTAAGTTTAAAACCTGGG------------- 6603
Rat 4745 TCATTTCGTTGAGCTTAAAATCTGCG------------- 4770
Mouse 4834 ACATTTCGTTGAGTCTAAAATCTGCG------------- 4859
Zebrafish 4296 -AGAAGCGGTGACTATTAGAACTGTG------------- 4320
Fruitfly 1237 ACG------------------------------------ 1239
Worm 1013 -------AGTGACTACCTGAATCGCGTCTCTGAATCTCC 1044
Yeast 406 --------------------------------------- 405
Arabidopsis 1974 TCAT-----TGG--------TC----------------- 1982
cons 9010 9048
Human 8105 ------------------ATGGACTTAAGTATTCATGTT 8125
Chimpanzee 6604 ------------------ATGGACTTAAGTATTCATG-- 6622
Rat 4771 ------------------ATGGATGTCAGTATTCA---- 4787
Mouse 4860 ------------------ATGGATGGCAGTATTCA---- 4876
Zebrafish 4321 -------------------TGAAGGGAATAATGC----- 4335
Fruitfly 1240 --------------------------------------- 1239
Worm 1045 ACACAATTCCTACTAAAGAC------------------- 1064
Yeast 406 --------------------------------------- 405
Arabidopsis 1983 --------------------------------------- 1982
cons 9049 9087
Human 8126 CATTCATGTTCATTCAGGACTG-CAGGTTATCATGACTT 8163
Chimpanzee 6623 --------TTCATTCAGGACTG-CAGGTTATCATGACTT 6652
Rat 4788 ----------------AGTCTG-CAGGTTATC---GCTT 4806
Mouse 4877 ----------------AGTCTG-TAGGTTATC---GCTT 4895
Zebrafish 4336 -----------ATAG---AATGACTGAAAATCGCC-TTC 4359
Fruitfly 1240 --------------------------------------- 1239
Worm 1065 --------------------------------------- 1064
Yeast 406 --------------------------------------- 405
Arabidopsis 1983 ------------TCCAGGGCTA-AAG-------CTGCTA 2001
cons 9088 9126
Human 8164 GTTTAA-CTTGTGG-GAAGCTGTTGTCCCAAGTTATCCT 8200
Chimpanzee 6653 GTTTAA-CTTGTGG-GAAGCTGTTGTCCCAAGTTATCCT 6689
Rat 4807 GGTTAC-CATATGG-G-AGCCGTCTTCCCAAGTTACCCT 4842
Mouse 4896 GGTTAC-CATATGG-G-AGCCGTCTTCCCAAGTTACCCT 4931
Zebrafish 4360 GATTACACAGATAATTGATTGATTTAAATAATGAAGTAA 4398
Fruitfly 1240 --------------------------------------- 1239
Worm 1065 --------------------------------------- 1064
Yeast 406 --------------------------------------- 405
Arabidopsis 2002 CGTTTC-CAAA--------------------G------- 2012
cons 9127 9165
Human 8201 GGGGAACTGCATCTGGTTC-TTGCA-AAACACCAAGTAG 8237
Chimpanzee 6690 GGGGAACTGCATCTGGTTC-ATGCA-AAACACCAAGTAG 6726
Rat 4843 CGGGAGATGAATCTGGTTC-ATGCA-GAACACCAAGTAG 4879
Mouse 4932 CGGGAGATGCATCTGGGTC-ATGCA-GAACACCAAGTAG 4968
Zebrafish 4399 TGAAAGATTTGTT-GTTTTATTGCATGCACATTAGGAAT 4436
Fruitfly 1240 --------------------------------------- 1239
Worm 1065 --------------------------------------- 1064
Yeast 406 --------------------------------------- 405
Arabidopsis 2013 -AAGAGAT---------TG-ATGTA-A-----TAAGGAG 2034
cons 9166 9204
Human 8238 -ACAGGCTCTCTTTTACCTCCCCTTGAGGGCATTAACA- 8274
Chimpanzee 6727 -ACAGGCTCTCTTTTACCTCCCCTTGAGGGCATTAACA- 6763
Rat 4880 TAAAAGCTCTTG----CC-C-ACTTCGGGCAGCTAACTT 4912
Mouse 4969 TAAAGGCTCTTG----CC-C-ACCTCGGGCAGCTAACTT 5001
Zebrafish 4437 -ACAGTAT-GTG----TT-C-AGTGT-GATGTCTTGG-- 4464
Fruitfly 1240 ------CTGGTG----CC-C-GCATCGGGTG-------- 1258
Worm 1065 ----------------------------------AATTT 1069
Yeast 406 --------------------------------------- 405
Arabidopsis 2035 ------G----TCCAACCTT-------AGAC-CTGGGT- 2054
cons 9205 9243
Human 8275 TTCAGTAGTCACTTCCA----TT---CAGTTAACCCTTT 8306
Chimpanzee 6764 TTCAGTAGTCACTTCCA----TT---CAGTTAACCCTTT 6795
Rat 4913 TTCAGTAGGCACTTCCT----TT---CAGTTGACCCTTT 4944
Mouse 5002 TTCAGTAGGCACTTCCTTCCTTG---CAGTTGACCCTTT 5037
Zebrafish 4465 TTTAGTAGATGTTTTAT----TACTGTAATGTACTGTCT 4499
Fruitfly 1259 ------CGGC--------------------------GTT 1265
Worm 1070 TTCA------------TTTCTTG------------CTTT 1084
Yeast 406 ------------TTGAA----GACT-------------- 414
Arabidopsis 2055 -TTGGTAG---------------------TTGT--GTGT 2069
cons 9244 9282
Human 8307 ATTTTTATGGTTTTTCTTGAGCCATAGTTGTAAAGCAGA 8345
Chimpanzee 6796 ATTTTTATGG-TTTTCTTGAGCCATAGTTGTAAAGCAGA 6833
Rat 4945 ATCCTTAGAA-TTTTCTTCAGCCCTATTGGTGAAGCAGA 4982
Mouse 5038 ATCCTTAGAA-TGCTCTTCAGCCCTATTGGTGAAGCAGA 5075
Zebrafish 4500 CT-CTTAGAC-ACGTC-GGAGACCT--GGGTAATG-TGA 4532
Fruitfly 1266 AT-------------------------TGG--------- 1270
Worm 1085 GTCGTTA-------------------------------- 1091
Yeast 415 ----------------------------GGTAA------ 419
Arabidopsis 2070 ATC-------------TTC--------TGGT-------- 2079
cons 9283 9321
Human 8346 AAAATCATT-TATAAAGGTTTGTTGAAC-AAA-ATTCAA 8381
Chimpanzee 6834 AAAATCATT-TATAAAGGTTTGTTGAAC-AAA-ATTCAA 6869
Rat 4983 ACAATCATT-CATAAATGTTCTAAAAAT-AAA-ATTTAA 5018
Mouse 5076 ACAGTCATT-CATAAGTGTT-GTAAAAT-AAAGCTTTAG 5111
Zebrafish 4533 CCGCTGATGCCAGTGGTGTTGCAAAAATTGAA-ATCGAG 4570
Fruitfly 1271 -----CATT-GCCA-AGGT-C------------------ 1283
Worm 1092 -----TATT-C-----------T-----------TAA-G 1101
Yeast 420 -------TG------------------------------ 421
Arabidopsis 2080 ---------------G-TGTGGCTAAA---AA-CCTATG 2098
cons 9322 9360
Human 8382 AATACTGTTGCTTAAAG--------TATTAAGATTTTTT 8412
Chimpanzee 6870 AATACTGTTGCT-AAAG--------TATTAAGATTTTTT 6899
Rat 5019 AATCTTGTTGCT-A-AG--------TA--AAGATA-TTT 5044
Mouse 5112 AGTCTTGTTGCT-A-AG--------TA--GAGATA-CTT 5137
Zebrafish 4571 GATG-CAATGCT-G-AC--------TC--TGTCAGGCC- 4595
Fruitfly 1284 -----------T-A-AGCGATAATCTA--TT-------- 1299
Worm 1102 AATCCCGTTGTT--------------------------- 1113
Yeast 422 ----------C----------------------CG---- 424
Arabidopsis 2099 AG------------------------------------- 2100
cons 9361 9399
Human 8413 AGGATTATACCTTACTTATAGGCCCG----TCATTCATT 8447
Chimpanzee 6900 AGGATTATACCTTACTTATAGGCCTG----TCATTCATT 6934
Rat 5045 AGAATTGCCTCTTATGTGTAGGCCTA----TAGTTCACT 5079
Mouse 5138 AGAATTGCCTCTTATGTGTAGGCCTA----TAGTTCTTT 5172
Zebrafish 4596 A--ACATTCTATTATTGGGAGGACCA----TGGTGG--T 4626
Fruitfly 1300 ----------CCGAT--GTCGG----------------- 1309
Worm 1114 ----------------------CCTACTCCT-------- 1122
Yeast 425 --------------------------------------- 424
Arabidopsis 2101 ----------CTTA-GTGT-GGCTCA----AAGCATTTT 2123
cons 9400 9438
Human 8448 TGGCATGAAATTT-TGAGTTTTATTCACTTTCACTTTCC 8485
Chimpanzee 6935 TGGCATGAAATTT-TGAGTTTTATTCACTTTCACTTTCC 6972
Rat 5080 CACCAAGAGATTT-TGAT--------------------- 5096
Mouse 5173 CAACATGAGATTT-TGAT--------------------- 5189
Zebrafish 4627 AAGGAAGACATCATTTAT--------------------- 4644
Fruitfly 1310 --------------------------------------- 1309
Worm 1123 --------------------------------------- 1122
Yeast 425 --------------------------------------- 424
Arabidopsis 2124 TA-------ATTC-AGAC--------------------- 2133
cons 9439 9477
Human 8486 TTTTTTTCCAAAGCAATTAAA-AAAACTGCCAAAGTAAG 8523
Chimpanzee 6973 TTTTTTTCCAAAGCAATTAAA-AAAACTGCCAAAGTAAG 7010
Rat 5097 ---------AGAGAAAT----------T-----TGTAAG 5111
Mouse 5190 ---------AGAGAAAT----------T-----TGTAAG 5204
Zebrafish 4645 ---------AAAA------AGCGGCACA-----TTAAAT 4663
Fruitfly 1310 --------------------------------------- 1309
Worm 1123 --------------------------------------- 1122
Yeast 425 --------------------------------------- 424
Arabidopsis 2134 -----------AG------AA------------------ 2137
cons 9478 9516
Human 8524 AGTGACTGCGGAACTAAGGTTACTGTAACTTACCATGGA 8562
Chimpanzee 7011 AGTGACTGCGGAACTAAGGTTAATGTAACTTACCATGGA 7049
Rat 5112 AATGACTACTGTACAGTGG-------GG-TGAGGG-TGA 5141
Mouse 5205 AATGACTACTGTGT------------AG-TTGG---GGA 5227
Zebrafish 4664 GACAATAACTGTGC------------AA-TAACAGCC-- 4687
Fruitfly 1310 -----CCACTGTGC---------------TG-------- 1320
Worm 1123 ----ACTACTGTAT------------------------- 1132
Yeast 425 --------------------------------------- 424
Arabidopsis 2138 ------AAC---A--GAGA-------------------- 2145
cons 9517 9555
Human 8563 G-GATTAAGG-GTAGCGTGTGGTGGTCTACAACATAGTT 8599
Chimpanzee 7050 G-GATTAAGG-GTAGCGTGTGGTGGTCTAC--AACAGTT 7084
Rat 5142 G-GGCTAAGA-TCAGCATGTGC----CTG----GTAGTT 5170
Mouse 5228 GGAGCTAAGA-TCAGCATGTAC----CTG----GTAGTT 5257
Zebrafish 4688 G-ACCTC-----TTGTGTCTTC----CTGC--TGTAGAT 4714
Fruitfly 1321 ---------A-----------T----CTA----CT--C- 1328
Worm 1133 --------------------------------------- 1132
Yeast 425 -------------------------------------GT 426
Arabidopsis 2146 -------AAATTC----CG-------------------T 2154
cons 9556 9594
Human 8600 ATTTGGGTT-TTAGTATTTCATTTAGACA--GCAAC-AC 8634
Chimpanzee 7085 ATTTGGGTT-TTAGTATTTCATTTAGACATAGCAAC-AC 7121
Rat 5171 ATTTGGGTCCTTAGTAT-TCATCTAGAAATAGCCAC-G- 5206
Mouse 5258 ACTTGGGTC-TTAGTATTTCATCTAGAAATAGCCAC-T- 5293
Zebrafish 4715 TCATGAGAA-GGAGGATGACTT----------------- 4735
Fruitfly 1329 -------------------TATTTAGCACTACCCACTG- 1347
Worm 1133 ATT-------------TT-CA------CA---------- 1141
Yeast 427 CCA------------------------------------ 429
Arabidopsis 2155 ACT-----T-TTATTATTTCATG----AATA-------- 2175
cons 9595 9633
Human 8635 TTACCTAATGTTTAAAGGTAATGTCTTTGCAACACCAAG 8673
Chimpanzee 7122 TTACCTAATGTTTAAAGGTAATGTCTTTGCAACACCAAG 7160
Rat 5207 ---------------------------------AGCAAG 5212
Mouse 5294 ---------------------------------AGCAAG 5299
Zebrafish 4736 --------------------------------------- 4735
Fruitfly 1348 --------------------------------------- 1347
Worm 1142 --------------------------------------- 1141
Yeast 430 --------------------------------------- 429
Arabidopsis 2176 --------------------------------------- 2175
cons 9634 9672
Human 8674 AAAA----AGCTTTGAGTAGTAGTTTCTACTTTTAAACT 8708
Chimpanzee 7161 AAAA----AGCTTTGAGTAGTAGTTTCTACTTTTAAACT 7195
Rat 5213 GAAA----CACTT--AGTAGT-----CTGCTTTTA-GCT 5239
Mouse 5300 GAAA----AACTT--AGTGGT-----CTGCTCTTA-ACT 5326
Zebrafish 4736 --------------------------------------- 4735
Fruitfly 1348 GAGATATAC------------------------------ 1356
Worm 1142 --------------------------------------- 1141
Yeast 430 --------------------------------------- 429
Arabidopsis 2176 --------------------------------------- 2175
cons 9673 9711
Human 8709 A-----CTAAATATTAGTATATCTCTCTACTAGGATTAA 8742
Chimpanzee 7196 A-----CTAAATATTAGTATATCTCTCTACTAGGATTAA 7229
Rat 5240 GATAGCATAAAAATTAGCTTATTGATTTACTAATAGATT 5278
Mouse 5327 G-----C-------TAGT----------------ATT-- 5335
Zebrafish 4736 --------------------------------------- 4735
Fruitfly 1357 -AAACG------------------ATATAC--ATACTTC 1374
Worm 1142 --------------------------------------- 1141
Yeast 430 --------------------------------------- 429
Arabidopsis 2176 --------------------------------------- 2175
cons 9712 9750
Human 8743 TGTTATTTTTCTAATATTATGAGGTTCTTAAACATCTTT 8781
Chimpanzee 7230 TGTTATTTTTCTAATATTATGAGGTTCTTAAACATCTTT 7268
Rat 5279 TGAACATTTTCTAATAT-ACATGGTC---------CTTT 5307
Mouse 5336 -----------TAA---------GT----------C--T 5342
Zebrafish 4736 --------------------------------------- 4735
Fruitfly 1375 TAAACATA----A--AT-ACATAGCC----------T-- 1394
Worm 1142 --------------------------------------- 1141
Yeast 430 --------------------------------------- 429
Arabidopsis 2176 --------------------------------------- 2175
cons 9751 9789
Human 8782 TGGGTATTGTTGGGAGGAGGTAGTGATT-ACTTGACAGC 8819
Chimpanzee 7269 TGGGTATTGTTGGGAGGAGGTAGTGATT-ACTTGACAGC 7306
Rat 5308 GAAGTATTGCTGGGAAGAAGTGCTAATT-ACTTGATCAC 5345
Mouse 5343 GTAGTATTGCTGGGAAGAAGTACTAGTT-ACTTGATCAT 5380
Zebrafish 4736 --------------------------------------- 4735
Fruitfly 1395 GTGGT------------------CTGTT-AGTTGAT-AC 1413
Worm 1142 --------------------------------------- 1141
Yeast 430 --------------------------------------- 429
Arabidopsis 2176 --------------AAAAAGAGTTGATTTAC-TG----- 2194
cons 9790 9828
Human 8820 CCAAAGTT--A-TCTTCTTAAAATTTTTTACAGGTCCAT 8855
Chimpanzee 7307 CCAAAGTT--A-TCTTCTTAAAATTTTTTACAGGTCCAT 7342
Rat 5346 CGAAACCTAAA-TGTTCTTAATTCTTTTCAAAGGTCCAC 5383
Mouse 5381 TCAAACCTAAA-TGTTCTT----CTTTTCAAAGGTCCAT 5414
Zebrafish 4736 --------------------------------------- 4735
Fruitfly 1414 G-CAAC-----------------CTT-T--GAGGTTCA- 1430
Worm 1142 -------TAAAAT-TTCT---------TCAAAATTTCA- 1162
Yeast 430 --------------------------------------- 429
Arabidopsis 2195 ------TTATA-AGTTC----------TTAAAGGT---- 2212
cons 9829 9867
Human 8856 GAAAAAGCAGATGACTTGGGCAAAGGTGGAAATGAAGAA 8894
Chimpanzee 7343 GAAAAAGCAGATGACTTGGGCAAAGGTGGAAATGAAGAA 7381
Rat 5384 GAGAAACAAGATGACTTGGGCAAAGGTGGAAATGAAGAA 5422
Mouse 5415 GAGAAACAAGATGACTTGGGCAAAGGTGGAAATGAAGAA 5453
Zebrafish 4736 -----------------GGGGAAGGGTGGCAATGAGGAA 4757
Fruitfly 1431 -------------------------------AT----A- 1433
Worm 1163 ------------------------------AAT------ 1165
Yeast 430 --------------------------------------- 429
Arabidopsis 2213 ----AACAAGA-GTCCT---------------------- 2224
cons 9868 9906
Human 8895 AGTACAAAGACAGGAAACGCTGGAA--GTCGTTTGGCTT 8931
Chimpanzee 7382 AGTACAAAGACAGGAAACGCTGGAA--GTCGTTTGGCTT 7418
Rat 5423 AGTACAAAGACTGGAAATGCTGGAA--GCCGCTTGGCTT 5459
Mouse 5454 AGTACAAAGACTGGAAATGCTGGGA--GCCGCTTGGCCT 5490
Zebrafish 4758 AGTCTTAAAACTGGCAACGCTGGTG--GTCGTCTGGCCT 4794
Fruitfly 1434 ---------------AA---------------TT----- 1437
Worm 1166 -----AAAG---------G-------------T-----T 1172
Yeast 430 -------AGAC----------------------CAGCCT 439
Arabidopsis 2225 ------------GGATATGGT---ACTTCAATATGCG-- 2246
cons 9907 9945
Human 8932 GTGGTGTAATTGGGATCGCCCAATAAACATTCCCTTGGA 8970
Chimpanzee 7419 GTGGTGTAATTGGGATCGCCCA----------------- 7440
Rat 5460 GTGGTGTGATTGGGATTGCCCAATAAACATTCCC----- 5493
Mouse 5491 GTGGAGTGATTGGGATTGCGCAGTAAACATTCCC----- 5524
Zebrafish 4795 GTGGAGTGATCGGCATCACTCAGTGAATCTGCTCT--AA 4831
Fruitfly 1438 --GGTGTT-TTG--------------------------- 1446
Worm 1173 --------------------------------------- 1172
Yeast 440 GTGGTGTCATT---------------------------- 450
Arabidopsis 2247 --------AAT------GT-------------------- 2251
cons 9946 9984
Human 8971 TGTAGTCTGAGGCCCCTTAACTCATCTGTTATCCTGCTA 9009
Chimpanzee 7441 --------------------------------------- 7440
Rat 5494 --------------------------------------- 5493
Mouse 5525 --------------------------------------- 5524
Zebrafish 4832 TGGA---AGA-GCCGGTTGAAATATTGGTGACC------ 4860
Fruitfly 1447 --------------------------------------- 1446
Worm 1173 --------------------------------------- 1172
Yeast 451 --------------------------------------- 450
Arabidopsis 2252 --------------------------------------- 2251
cons 9985 10023
Human 9010 GCTGTAGAAATGTATCCTGATAAACATTAAACACTGTAA 9048
Chimpanzee 7441 --------------------------------------- 7440
Rat 5494 --------------------------------------- 5493
Mouse 5525 --------------------------------------- 5524
Zebrafish 4861 AATGTGGAT--GCCT-CTGA-AAGCACTTAGCCCG---- 4891
Fruitfly 1447 --------------------------------------- 1446
Worm 1173 --------------------------------------- 1172
Yeast 451 --------------------------------------- 450
Arabidopsis 2252 --------------------------------------- 2251
cons 10024 10062
Human 9049 TCTTAAAAGTGTAATTGTGTGACTTTTTCAGAGTTGCTT 9087
Chimpanzee 7441 --------------------------------------- 7440
Rat 5494 --------------------------------------- 5493
Mouse 5525 --------------------------------------- 5524
Zebrafish 4892 -CTGA------CAATTACATCTCTATTT-----TTG--- 4915
Fruitfly 1447 --------------------------------------- 1446
Worm 1173 --------------------------------------- 1172
Yeast 451 --------------------------------------- 450
Arabidopsis 2252 --------------------------------------- 2251
cons 10063 10101
Human 9088 TAAAGTACCTGTAGTGAGAAACTGATTTATGATCACTTG 9126
Chimpanzee 7441 --------------------------------------- 7440
Rat 5494 --------------------------------------- 5493
Mouse 5525 --------------------------------------- 5524
Zebrafish 4916 TTAGGTA-------------AC--------G-----TTG 4928
Fruitfly 1447 --------------------------------------- 1446
Worm 1173 --------------------------------------- 1172
Yeast 451 --------------------------------------- 450
Arabidopsis 2252 --------------------------------------- 2251
cons 10102 10140
Human 9127 GAAGATTTGTATAGTTTTATAAAACTCAGTTAAAATGTC 9165
Chimpanzee 7441 --------------------------------------- 7440
Rat 5494 --------------------------------------- 5493
Mouse 5525 --------------------------------------- 5524
Zebrafish 4929 AAAGAATTGTAC--T-TT----AGCCTTGTTAAGCTGTT 4960
Fruitfly 1447 --------------------------------------- 1446
Worm 1173 --------------------------------------- 1172
Yeast 451 --------------------------------------- 450
Arabidopsis 2252 --------------------------------------- 2251
cons 10141 10179
Human 9166 TGTTTCAATGACCTGTATTTTGCCAGACTTAAATCACAG 9204
Chimpanzee 7441 --------------------------------------- 7440
Rat 5494 ------------------------------------TAT 5496
Mouse 5525 ------------------------------------TGT 5527
Zebrafish 4961 T--TTC--TG---TGCATTT--C-------------TAT 4977
Fruitfly 1447 --------------------------------------- 1446
Worm 1173 --------------------------------------- 1172
Yeast 451 --------------------------------------- 450
Arabidopsis 2252 --------------------------------------- 2251
cons 10180 10218
Human 9205 ATGGGTATTAAACTTGTCAGAAT--TTCTTTGTCATTCA 9241
Chimpanzee 7441 --------------------------------------- 7440
Rat 5497 GTGGTCT---GAGTC-TC---AGACTCATCTGCTGTCC- 5527
Mouse 5528 GTGGTCT---GAGTC-TC---AGACTCATCTGCTACC-- 5557
Zebrafish 4978 GTGGGCA---ACCTT----------TTATTTGTTATC-- 5001
Fruitfly 1447 -----------A--------------------------- 1447
Worm 1173 --------------------------------------- 1172
Yeast 451 --GGTCT-------------------------------- 455
Arabidopsis 2252 --------------------------------------- 2251
cons 10219 10257
Human 9242 AGCCTGTGAATAAAAACCCTGTATGGCACTTA-T----- 9274
Chimpanzee 7441 --------------------------------------- 7440
Rat 5528 ----TGCT--AA---AC------------TGTAGAAAAA 5545
Mouse 5558 ----------------C------------TC-------- 5560
Zebrafish 5002 ----TGCT--TA---AT------------TCA-T----- 5013
Fruitfly 1448 --------------------------------------- 1447
Worm 1173 --------------------------------------- 1172
Yeast 456 -----------A---A----------------------- 457
Arabidopsis 2252 --------------------------------------- 2251
cons 10258 10296
Human 9275 ----TATGAGGCTATTAAAAGAATCCA---AATTCAAAC 9306
Chimpanzee 7441 --------------------------------------A 7441
Rat 5546 AACCAA---ACC-ATTA------AACTGTAATC-----T 5569
Mouse 5561 ----AA---ACC-ATTA------AACTGTAATC-----T 5580
Zebrafish 5014 ----TA---AAC-ATTG------AGCA---GACTG---G 5032
Fruitfly 1448 -----------------------AATTG---CC-----C 1455
Worm 1173 ---------------------------GTAGT------T 1178
Yeast 458 ----------CC-----------A-------AC------ 462
Arabidopsis 2252 --------------------------------------T 2252
cons 10297 10335
Human 9307 -----TAA 9309
Chimpanzee 7442 -----TAA 7444
Rat 5570 TAACAGTT 5577
Mouse 5581 -----GAA 5583
Zebrafish 5033 -----AAA 5035
Fruitfly 1456 -----CAT 1458
Worm 1179 -----TCC 1181
Yeast 463 -----TAA 465
Arabidopsis 2253 -----TTT 2255
cons 10336 10343